Article (Scientific journals)
Fundamentalproperties of Ca2+ signals
THURLEY, K.; SKUPIN, Alexander; Thul, R. et al.
2012In Biochimica et Biophysica Acta - General Subjects, 1820 (8), p. 1185-94
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Abstract :
[en] Background Ca2 + is a ubiquitous and versatile second messenger that transmits information through changes of the cytosolic Ca2 + concentration. Recent investigations changed basic ideas on the dynamic character of Ca2 +signals and challenge traditional ideas on information transmission. Scope of review We present recent findings on key characteristics of the cytosolic Ca2 + dynamics and theoretical concepts that explain the wide range of experimentally observed Ca2 +signals. Further, we relate properties of the dynamical regulation of the cytosolic Ca2 + concentration to ideas about information transmission by stochastic signals. Major conclusions We demonstrate the importance of the hierarchal arrangement of Ca2 + release sites on the emergence of cellular Ca2 + spikes. Stochastic Ca2 +signals are functionally robust and adaptive to changing environmental conditions. Fluctuations of interspike intervals (ISIs) and the moment relation derived from ISI distributions contain information on the channel cluster open probability and on pathway properties. General significance Robust and reliable signal transduction pathways that entail Ca2 + dynamics are essential for eukaryotic organisms. Moreover, we expect that the design of a stochastic mechanism which provides robustness and adaptivity will be found also in other biological systems. Ca2 + dynamics demonstrate that the fluctuations of cellular signals contain information on molecular behavior. This article is part of a Special Issue entitled Biochemical, biophysical and genetic approaches to intracellular calcium signaling.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Integrative Cell Signalling (Skupin Group)
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
Disciplines :
Life sciences: Multidisciplinary, general & others
Identifiers :
Author, co-author :
THURLEY, K. ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
SKUPIN, Alexander  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Thul, R.
Falcke, M.
External co-authors :
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Title :
Fundamentalproperties of Ca2+ signals
Publication date :
Journal title :
Biochimica et Biophysica Acta - General Subjects
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
Issue :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
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