Article (Scientific journals)
Fundamentalproperties of Ca2+ signals
THURLEY, K.; SKUPIN, Alexander; Thul, R. et al.
2012In Biochimica et Biophysica Acta - General Subjects, 1820 (8), p. 1185-94
Peer Reviewed verified by ORBi
 

Files


Full Text
Biochim. Biophys. Acta 2012 Thurley.pdf
Publisher postprint (705.84 kB)
Request a copy

All documents in ORBilu are protected by a user license.

Send to



Details



Abstract :
[en] Background Ca2 + is a ubiquitous and versatile second messenger that transmits information through changes of the cytosolic Ca2 + concentration. Recent investigations changed basic ideas on the dynamic character of Ca2 +signals and challenge traditional ideas on information transmission. Scope of review We present recent findings on key characteristics of the cytosolic Ca2 + dynamics and theoretical concepts that explain the wide range of experimentally observed Ca2 +signals. Further, we relate properties of the dynamical regulation of the cytosolic Ca2 + concentration to ideas about information transmission by stochastic signals. Major conclusions We demonstrate the importance of the hierarchal arrangement of Ca2 + release sites on the emergence of cellular Ca2 + spikes. Stochastic Ca2 +signals are functionally robust and adaptive to changing environmental conditions. Fluctuations of interspike intervals (ISIs) and the moment relation derived from ISI distributions contain information on the channel cluster open probability and on pathway properties. General significance Robust and reliable signal transduction pathways that entail Ca2 + dynamics are essential for eukaryotic organisms. Moreover, we expect that the design of a stochastic mechanism which provides robustness and adaptivity will be found also in other biological systems. Ca2 + dynamics demonstrate that the fluctuations of cellular signals contain information on molecular behavior. This article is part of a Special Issue entitled Biochemical, biophysical and genetic approaches to intracellular calcium signaling.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Integrative Cell Signalling (Skupin Group)
Luxembourg Centre for Systems Biomedicine (LCSB): Experimental Neurobiology (Balling Group)
Disciplines :
Life sciences: Multidisciplinary, general & others
Identifiers :
UNILU:UL-ARTICLE-2012-379
Author, co-author :
THURLEY, K. ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
SKUPIN, Alexander  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Thul, R.
Falcke, M.
External co-authors :
yes
Language :
English
Title :
Fundamentalproperties of Ca2+ signals
Publication date :
2012
Journal title :
Biochimica et Biophysica Acta - General Subjects
ISSN :
1872-8006
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
1820
Issue :
8
Pages :
1185-94
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 03 November 2015

Statistics


Number of views
70 (9 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
69
Scopus citations®
without self-citations
58
WoS citations
 
66

Bibliography


Similar publications



Contact ORBilu