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A biophysical model for modulation frequency encoding in the cochlear nucleus.
Eguia, Manuel C.; Garcia, Guadalupe Clara; Romano, Sebastian A.
2010In Journal of Physiology, 104 (3-4), p. 118-27
Peer reviewed
 

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Keywords :
Computational neuroscience; Auditory system; Cochlear nucleus; Temporal coding
Abstract :
[en] Encoding of amplitude modulated (AM) acoustical signals is one of the most compelling tasks for the mammalian auditory system: environmental sounds, after being filtered and transduced by the cochlea, become narrowband AM signals. Despite much experimental work dedicated to the comprehension of auditory system extraction and encoding of AM information, the neural mechanisms underlying this remarkable feature are far from being understood (Joris et al., 2004). One of the most accepted theories for this processing is the existence of a periodotopic organization (based on temporal information) across the more studied tonotopic axis (Frisina et al., 1990b). In this work, we will review some recent advances in the study of the mechanisms involved in neural processing of AM sounds, and propose an integrated model that runs from the external ear, through the cochlea and the auditory nerve, up to a sub-circuit of the cochlear nucleus (the first processing unit in the central auditory system). We will show that varying the amount of inhibition in our model we can obtain a range of best modulation frequencies (BMF) in some principal cells of the cochlear nucleus. This could be a basis for a synchronicity based, low-level periodotopic organization.
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Eguia, Manuel C.
Garcia, Guadalupe Clara ;  University of Buenos Aires > Physics Department
Romano, Sebastian A.
External co-authors :
yes
Language :
English
Title :
A biophysical model for modulation frequency encoding in the cochlear nucleus.
Publication date :
2010
Event name :
Neural Coding Workshop
Event place :
Montevideo, Uruguay
Event date :
2007
Audience :
International
Journal title :
Journal of Physiology
ISSN :
0928-4257
eISSN :
1769-7115
Volume :
104
Issue :
3-4
Pages :
118-27
Peer reviewed :
Peer reviewed
Commentary :
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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