Reference : Systems biology of host-microbe metabolomics
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Systems biology of host-microbe metabolomics
Heinken, Almut Katrin mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Thiele, Ines mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Wiley Interdisciplinary Reviews. Systems Biology and Medicine
Yes (verified by ORBilu)
[en] gut microbiota ; computational modeling ; host-microbe interaction ; metabolomics ; systems biology
[en] The human gut microbiota performs essential functions for host and wellbeing, but has also been linked to a variety of disease states, e.g., obesity and type 2 diabetes. The mammalian body fluid and tissue metabolomes are greatly influenced by the microbiota, with many health-relevant metabolites being considered “mammalian-microbial co-metabolites”. To systematically investigate this complex host-microbial co-metabolism, a systems biology approach integrating high-throughput data and computational network models is required. Here, we review established top-down and bottom-up systems biology approaches that have successfully elucidated relationships between gut microbiota-derived metabolites and host health and disease. We particularly focus on the constraint-based modeling and analysis approach, which enables the prediction of mechanisms behind metabolic host-microbe interactions on the molecular level. We illustrate that constraint-based models are a useful tool for the contextualization of metabolomic measurements and can further our insight into host-microbe interactions, yielding, e.g., in potential novel drugs and biomarkers.
Luxembourg Centre for Systems Biomedicine (LCSB): Molecular Systems Physiology (Thiele Group)

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