Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells.

Sachinidis, A.; Weisser, P.; Ko, Y.; Schulte, K.; Meyer zu Brickwedde, K.; Neyses, Ludwig; Vetter, H.

doi:10.1016/0014-5793(92)81423-J

Reference : Angiotensin II induces formation of the early growth response gene-1 protein in rat v...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Cardiovascular & respiratory systems
	To cite this reference:	http://hdl.handle.net/10993/18371

Title :	Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells.
Language :	English
Author, co-author :	Sachinidis, A. [> >]
	Weisser, P. [> >]
	Ko, Y. [> >]
	Schulte, K. [> >]
	Meyer zu Brickwedde, K. [> >]
	Neyses, Ludwig [University of Luxembourg > Research Office]
	Vetter, H. [> >]
Publication date :	1992
Journal title :	FEBS letters
Volume :	313
Issue/season :	2
Pages :	109-12
Peer reviewed :	Yes (verified by ORBi^lu)
Audience :	International
ISSN :	0014-5793
Country :	NETHERLANDS
Keywords :	[en] Angiotensin II/pharmacology ; Animals ; Cells, Cultured ; DNA-Binding Proteins/biosynthesis/genetics ; Early Growth Response Protein 1 ; Female ; Immediate-Early Proteins ; Muscle, Smooth, Vascular/drug effects/metabolism ; Phosphatidylinositols/metabolism ; RNA, Messenger/analysis ; Rats ; Rats, Inbred WKY ; Transcription Factors/biosynthesis/genetics
Abstract :	[en] The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositol phosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene.
Permalink :	http://hdl.handle.net/10993/18371
DOI :	10.1016/0014-5793(92)81423-J
Other URL :	http://www.sciencedirect.com/science/article/pii/001457939281423J#

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