Article (Scientific journals)
Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells.
Sachinidis, A.; Weisser, P.; Ko, Y. et al.
1992In FEBS Letters, 313 (2), p. 109-12
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Keywords :
Angiotensin II/pharmacology; Animals; Cells, Cultured; DNA-Binding Proteins/biosynthesis/genetics; Early Growth Response Protein 1; Female; Immediate-Early Proteins; Muscle, Smooth, Vascular/drug effects/metabolism; Phosphatidylinositols/metabolism; RNA, Messenger/analysis; Rats; Rats, Inbred WKY; Transcription Factors/biosynthesis/genetics
Abstract :
[en] The effect of angiotensin II (Ang II) on the early growth response gene-1 (Egr-1) mRNA, on the Egr-1 protein and on the phosphoinositide PI turnover signalling system was investigated in the presence and absence of EXP3174, a potent non-peptide Ang II receptor antagonist. Ang II induced an accumulation of 3.4 kb Egr-1 mRNA and the 80 kDa Egr-1 protein, with a maximum at 30 min and 60 min, respectively. EXP3174 blocked the Ang II-induced increase of inositol phosphates, Egr-1 mRNA and the Egr-1 protein, suggesting the involvement of the PI signalling system by the expression of the Egr-1 gene.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Sachinidis, A.
Weisser, P.
Ko, Y.
Schulte, K.
Meyer zu Brickwedde, K.
Neyses, Ludwig ;  University of Luxembourg > Research Office
Vetter, H.
Language :
English
Title :
Angiotensin II induces formation of the early growth response gene-1 protein in rat vascular smooth muscle cells.
Publication date :
1992
Journal title :
FEBS Letters
ISSN :
0014-5793
eISSN :
1873-3468
Publisher :
Wiley-Blackwell, United States
Volume :
313
Issue :
2
Pages :
109-12
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 16 October 2014

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