Reference : Ras-association domain family member 1A (RASSF1A)-where the heart and cancer meet.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Ras-association domain family member 1A (RASSF1A)-where the heart and cancer meet.
Oceandy, Delvac [> >]
Cartwright, Elizabeth J. [> >]
Neyses, Ludwig mailto [University of Luxembourg > Research Office]
Trends in cardiovascular medicine
Yes (verified by ORBilu)
United States
[en] Animals ; Cardiomegaly/genetics/metabolism/pathology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Genotype ; Humans ; Mice ; Mice, Knockout ; Myocardium/metabolism/pathology ; Neoplasms/genetics/metabolism/pathology ; Phenotype ; Protein Conformation ; Proto-Oncogene Proteins c-raf/metabolism ; Signal Transduction/genetics ; Structure-Activity Relationship ; Tumor Suppressor Proteins/chemistry/deficiency/genetics/metabolism ; ras Proteins/metabolism
[en] The close relationship between signaling pathways regulating tumor growth and cardiac hypertrophy has attracted considerable interest. Although the involvement of proto-oncogenes in positively modulating myocardial hypertrophy has long been recognized, little is known about factors that counterregulate them. In this article, we review the novel tumor suppressor Ras-association domain family protein isoform 1A (RASSF1A), which strongly inhibits the prohypertrophic Ras-Raf1-ERK1/2 pathway in the heart. RASSF1A interacts with a number of important signaling molecules regulating cell growth, survival, and apoptosis; therefore, it serves as a key adaptor molecule that integrates the upstream stimuli and transduces them to the selective downstream effectors.
Copyright 2009 Elsevier Inc. All rights reserved.

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