Reference : Calcium signaling dysfunction in heart disease.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Calcium signaling dysfunction in heart disease.
Cartwright, Elizabeth J. [> >]
Mohamed, Tamer [> >]
Oceandy, Delvac [> >]
Neyses, Ludwig mailto [University of Luxembourg > Research Office]
BioFactors (Oxford, England)
Yes (verified by ORBilu)
[en] Animals ; Calcium/metabolism ; Calcium Signaling/physiology ; Cardiomegaly/metabolism/physiopathology ; Heart Diseases/metabolism/physiopathology ; Humans ; Models, Biological
[en] In the heart, Ca(2+) is crucial for the regulation of contraction and intracellular signaling, processes, which are vital to the functioning of the healthy heart. Ca(2+) -activated signaling pathways must function against a background of large, rapid, and tightly regulated changes in intracellular free Ca(2+) concentrations during each contraction and relaxation cycle. This review highlights a number of proteins that regulate signaling Ca(2+) in both normal and pathological conditions including cardiac hypertrophy and heart failure, and discusses how these pathways are not regulated by the marked elevation in free intracellular calcium ([Ca(2+) ](i)) during contraction but require smaller sustained increases in Ca(2+) concentration. In addition, we present published evidence that the pool of Ca(2+) that regulates signaling is compartmentalized into distinct cellular microdomains and is thus distinct from that regulating contraction.
Copyright (c) 2011 International Union of Biochemistry and Molecular Biology, Inc.

File(s) associated to this reference

Fulltext file(s):

Limited access
Calcium signaling dysfunction in heart disease.pdfPublisher postprint159.73 kBRequest a copy

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.