Reference : Biomarker-guided therapies in heart failure: a forum for unified strategies.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Biomarker-guided therapies in heart failure: a forum for unified strategies.
Fiuzat, Mona [> >]
O'Connor, Christopher M. [> >]
Gueyffier, Francois [> >]
Mascette, Alice M. [> >]
Geller, Nancy L. [> >]
Mebazaa, Alexandre [> >]
Voors, Adriaan A. [> >]
Adams, Kirkwood F. [> >]
Pina, Ileana L. [> >]
Neyses, Ludwig mailto [University of Luxembourg > Central Administration >]
Muntendam, Pieter [> >]
Felker, G. Michael [> >]
Pitt, Bertram [> >]
Zannad, Faiez [> >]
Bristow, Michael R. [> >]
Journal of cardiac failure
Yes (verified by ORBilu)
United States
[en] Pharmacogenetics ; biologic markers ; cardiovascular diseases ; clinical trials
[en] The complexity of standard medical treatment for heart failure is growing, and such therapy typically involves 5 or more different medications. Given these pressures, there is increasing interest in harnessing cardiovascular biomarkers for clinical application to more effectively guide diagnosis, risk stratification, and therapy. It may be possible to realize an era of personalized medicine for heart failure treatment in which therapy is optimized and costs are controlled. The direct mechanistic coupling of biologic processes and therapies achieved in cancer treatment remains elusive in heart failure. Recent clinical trials and meta-analyses of biomarkers in heart failure have produced conflicting evidence. In this article, which comprises a summary of discussions from the Global Cardiovascular Clinical Trialists Forum held in Paris, France, we offer a brief overview of the background and rationale for biomarker testing in heart failure, describe opportunities and challenges from a regulatory perspective, and summarize current positions from government agencies in the United States and European Union.
Copyright (c) 2013 Elsevier Inc. All rights reserved.

File(s) associated to this reference

Fulltext file(s):

Open access
Biomarker-guided therapies in heart failure a forum for unified strategies.pdfPublisher postprint329.45 kBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.