Article (Scientific journals)
JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms
Gäbler, Karoline; Behrmann, Iris; Haan, Claude
2013In JAK-STAT, 2 (3), p. 25025
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Abstract :
[en] The Janus kinase 2 (JAK2) mutant V617F and other JAK mutants are found in patients with myeloproliferative neoplasms and leukemias. Due to their involvement in neoplasia and inflammatory disorders, Janus kinases are promising targets for kinase inhibitor therapy. Several small-molecule compounds are evaluated in clinical trials for myelofibrosis, and ruxolitinib (INCB018424, Jakafi®) was the first Janus kinase inhibitor to receive clinical approval. In this review we provide an overview of JAK2V617F signaling and its inhibition by small-molecule kinase inhibitors. In addition, myeloproliferative neoplasms are discussed regarding the role of JAK2V617F and other mutant proteins of possible relevance. We further give an overview about treatment options with special emphasis on possible combination therapies.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Gäbler, Karoline;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Behrmann, Iris ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Haan, Claude ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
English
Title :
JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms
Publication date :
2013
Journal title :
JAK-STAT
ISSN :
2162-3988
Publisher :
Landes Bioscience
Special issue title :
JAKSTAT
Volume :
2
Issue :
3
Pages :
e25025
Peer reviewed :
Peer reviewed
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since 23 May 2014

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