Reference : A community effort towards a knowledge-base and mathematical model of the human patho...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/10993/16517
A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2.
English
Thiele, Ines mailto [> >]
Hyduke, Daniel R. [> >]
Steeb, Benjamin [> >]
Fankam, Guy [> >]
Allen, Douglas K. [> >]
Bazzani, Susanna [> >]
Charusanti, Pep [> >]
Chen, Feng-Chi [> >]
Fleming, Ronan MT mailto [> >]
Hsiung, Chao A. [> >]
De Keersmaecker, Sigrid C. J. [> >]
Liao, Yu-Chieh [> >]
Marchal, Kathleen [> >]
Mo, Monica L. [> >]
Ozdemir, Emre [> >]
Raghunathan, Anu [> >]
Reed, Jennifer L. [> >]
Shin, Sook-Il [> >]
Sigurbjornsdottir, Sara [> >]
Steinmann, Jonas [> >]
Sudarsan, Suresh [> >]
Swainston, Neil [> >]
Thijs, Inge M. [> >]
Zengler, Karsten [> >]
Palsson, Bernhard O. [> >]
Adkins, Joshua N. [> >]
Bumann, Dirk [> >]
2011
BMC Systems Biology
5
8
Yes (verified by ORBilu)
1752-0509
England
[en] Anti-Bacterial Agents/metabolism/pharmacology ; Cooperative Behavior ; Databases, Factual ; Genes, Bacterial/genetics ; Humans ; Metabolic Networks and Pathways ; Models, Biological ; Salmonella typhimurium/drug effects/genetics/metabolism ; Systems Biology
[en] BACKGROUND: Metabolic reconstructions (MRs) are common denominators in systems biology and represent biochemical, genetic, and genomic (BiGG) knowledge-bases for target organisms by capturing currently available information in a consistent, structured manner. Salmonella enterica subspecies I serovar Typhimurium is a human pathogen, causes various diseases and its increasing antibiotic resistance poses a public health problem. RESULTS: Here, we describe a community-driven effort, in which more than 20 experts in S. Typhimurium biology and systems biology collaborated to reconcile and expand the S. Typhimurium BiGG knowledge-base. The consensus MR was obtained starting from two independently developed MRs for S. Typhimurium. Key results of this reconstruction jamboree include i) development and implementation of a community-based workflow for MR annotation and reconciliation; ii) incorporation of thermodynamic information; and iii) use of the consensus MR to identify potential multi-target drug therapy approaches. CONCLUSION: Taken together, with the growing number of parallel MRs a structured, community-driven approach will be necessary to maximize quality while increasing adoption of MRs in experimental design and interpretation.
http://hdl.handle.net/10993/16517
10.1186/1752-0509-5-8

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