[en] Herein, we study the feasibility of enhanced information throughput capability of multiple input multiple output orthogonal frequency division multiplexing (MIMO-OFDM) based wireless communication systems in the context of increasing wireless capacity demand. The concept of fractional sampling (FS) is exploited for this purpose to take advantage of diversity created because of it. Furthermore, a novel channel adaptive iterative sequence detector is proposed using the FS technique. The performance analysis of the proposed receiver is carried out, and a tighter performance bound is derived. It is found that the FS technique can improve bit error rate performance of MIMO and OFDM based systems provided that the noise samples are uncorrelated up to a certain level of FS rate. Moreover, it is observed that the performance improvement is a non-linear function of the FS rate. Besides this, the simulation results show that the proposed iterative receiver can significantly enhance the information throughput of MIMO-OFDM based wireless communication systems in comparison to conventional non-iterative receivers.