Reference : Mapping of the Mod-1 locus on mouse chromosome 9.
Scientific journals : Article
Life sciences : Genetics & genetic processes
Mapping of the Mod-1 locus on mouse chromosome 9.
Nass, S. J. [> >]
Olowson, M. [> >]
Miyashita, N. [> >]
Moriwaki, K. [> >]
Balling, Rudi mailto [> >]
Imai, K. [> >]
Mammalian Genome
Yes (verified by ORBilu)
[en] Animals ; Chromosome Mapping ; Crosses, Genetic ; Malate Dehydrogenase/genetics ; Mice ; Mice, Inbred C57BL ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length
[en] A new method for typing the Mod-1 locus on mouse Chromosome (Chr) 9 was developed, based on restriction fragment length polymorphism (RFLP) within a polymerase chain reaction (PCR)-amplified fragment. The new method led us to revise the strain distribution pattern (SDP) of Mod-1 in the BXD (C57BL/6J x DBA/2J) and AKXD (AKR/J x DBA/2J) recombinant inbred (RI) strains. The new SDP eliminates several previously reported examples of double recombination events between Mod-1 and the closest flanking loci in the BXD and AKXD strains. In the BXD strains, the revised SDP of Mod-1 was identical to that of the Mod-1-related D9Rtil locus. Thus, the identity of D9Rtil as a Mod-1-related locus rather than Mod-1 itself is in question. The method was also applied to an interspecific backcross panel between an inbred strain of Mus musculus molossinus (MSM/Ms) and C57BL/6J to map Mod-1 with respect to surrounding microsatellite loci, defining the proximal localization of Mod-1 with respect to D9Mit10 with a genetic distance of 0.6 +/- 0.6 cM.

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