Article (Scientific journals)
Nonequilibrium Thermodynamics of Chemical Reaction Networks: Wisdom from Stochastic Thermodynamics
Rao, Riccardo; Esposito, Massimiliano
2016In Physical Review X, 6 (4), p. 041064
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Abstract :
[en] We build a rigorous nonequilibrium thermodynamic description for open chemical reaction networks of <br /><br />elementary reactions. Their dynamics is described by deterministic rate equations with mass action <br /><br />kinetics. Our most general framework considers open networks driven by time-dependent chemostats. <br /><br />The energy and entropy balances are established and a nonequilibrium Gibbs free energy is introduced. <br /><br />The difference between this latter and its equilibrium form represents the minimal work done by the <br /><br />chemostats to bring the network to its nonequilibrium state. It is minimized in nondriven detailed-balanced <br /><br />networks (i.e., networks that relax to equilibrium states) and has an interesting information-theoretic <br /><br />interpretation. We further show that the entropy production of complex-balanced networks (i.e., networks <br /><br />that relax to special kinds of nonequilibrium steady states) splits into two non-negative contributions: one <br /><br />characterizing the dissipation of the nonequilibrium steady state and the other the transients due to <br /><br />relaxation and driving. Our theory lays the path to study time-dependent energy and information <br /><br />transduction in biochemical networks.
Disciplines :
Physics
Author, co-author :
Rao, Riccardo ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit
Esposito, Massimiliano  ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit
External co-authors :
no
Language :
English
Title :
Nonequilibrium Thermodynamics of Chemical Reaction Networks: Wisdom from Stochastic Thermodynamics
Publication date :
22 December 2016
Journal title :
Physical Review X
ISSN :
2160-3308
Publisher :
American Physical Society, College Park, United States - Maryland
Volume :
6
Issue :
4
Pages :
041064
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Physics and Materials Science
FnR Project :
FNR9114110 - Thermodynamic Cost Of Accuracy In Biological Processes, 2014 (01/11/2014-31/10/2018) - Riccardo Rao
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