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Article (Scientific journals)
Effects of nicotine administered via a transdermal delivery system on vigilance: a repeated measure study.
Mancuso, Giovanna; Andres, P.; Ansseau, M. et al.
1999In Psychopharmacology, 142 (1), p. 18-23
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Keywords :
Administration, Cutaneous; Adolescent; Adult; Analysis of Variance; Arousal/drug effects/physiology; Attention/drug effects; Humans; Male; Motor Activity/drug effects; Nicotine/administration & dosage/blood/pharmacology; Nicotinic Agonists/administration & dosage/blood/pharmacology; Reaction Time/drug effects
Abstract :
Fifteen 18- to 25-year-old male smokers were tested in a within-subjects design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Subjects were tested on the RVIP test (Rapid Visual Information Processing test) 1.30, 3.00 and 6.30 h after patch application, to verify the involvement of the dose of nicotine on the performance. This study confirms and extends the increasing effects of nicotine on vigilance previously found with orally and transdermally given nicotine. Moreover, it showed that such performance was independent of the time of nicotine absorption (1.30, 3.00 and 6.30 h after patch application), which suggests that a relatively low dose of nicotine suffices to activate vigilance processing. Regarding motor performance, no convincing effect of nicotine was observed on reaction time.
Disciplines :
Neurosciences & behavior
Author, co-author :
Mancuso, Giovanna ;  Université de Liège - ULg > fapse
Andres, P.
Ansseau, M.
Tirelli, E.
Language :
English
Title :
Effects of nicotine administered via a transdermal delivery system on vigilance: a repeated measure study.
Publication date :
1999
Journal title :
Psychopharmacology
ISSN :
0033-3158
Publisher :
Springer Verlag, Berlin, Germany
Volume :
142
Issue :
1
Pages :
18-23
Peer reviewed :
Peer reviewed
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since 26 September 2013

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