Article (Scientific journals)
Stress response and humoral immune system alterations related to chronic hypergravity in mice
GUEGUINOU, Nathan; Bojados, Mickael; Jamon, Marc et al.
2012In Psychoneuroendocrinology, 37 (1), p. 137-147
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Abstract :
[en] Spaceflights are known to induce stress and immune dysregulation. Centrifugation, as hindlimb unloading, is a good ground based-model to simulate altered gravity which occurs during space missions. The aim of this study was to investigate the consequences of a long-term exposure to different levels of hypergravity on the stress response and the humoral immunity in a mouse model. For this purpose, adult C57Bl/6J male mice were subjected for 21 days either to control conditions or to 2G or 3G acceleration gravity forces. Corticosterone level and anxiety behavior revealed a stress response which was associated with a decrease of body weight, after 21-day of centrifugation at 3G but not at 2G. Spleen lymphocyte lipopolysaccharide (LPS) responsiveness was diminished by 40% in the 2G group only, whereas a decrease was noted when cells were stimulated with concanavalin A for both 2G and 3G groups (about 25% and 20%, respectively) compared to controls. Pro-inflammatory chemokines (MCP-1 and IP-10) and Th1 cytokines (IFNγ and IL2) were slightly decreased in the 2G group and strongly decreased in the 3G mouse group. Regarding Th2 cytokines (IL4, IL5) no further significant modification was observed, whereas the immunosuppressive cytokine IL10 was slightly increased in the 3G mice. Finally, serum IgG concentration was twice higher whereas IgA concentration was slightly increased (about 30%) and IgM were unchanged in 2G mice compared to controls. No difference was observed in the 3G group with these isotypes. Consequently, functional immune dysregulations and stress responses were dependent of the gravity level.
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
UNILU:UL-ARTICLE-2013-008
Author, co-author :
GUEGUINOU, Nathan ;  Lorraine University, Vandoeuvre-lès-Nancy, France
Bojados, Mickael;  Aix-Marseille University, Marseille, France
Jamon, Marc;  Belgian Nuclear Research Center, Boeretang, Belgium
Derradji, Hanane
Baatout, Sarah
TSCHIRHART, Eric ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Frippiat, Jean-Pol
Legrand-Frossi, Christine
Language :
English
Title :
Stress response and humoral immune system alterations related to chronic hypergravity in mice
Publication date :
2012
Journal title :
Psychoneuroendocrinology
ISSN :
0306-4530
eISSN :
1873-3360
Publisher :
Pergamon Press (part of Elsevier Science), Oxford, United Kingdom
Volume :
37
Issue :
1
Pages :
137-147
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 13 September 2013

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