Reference : Nedocromil sodium inhibits IgE- and IgG-related antigen-induced contraction in guinea...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Nedocromil sodium inhibits IgE- and IgG-related antigen-induced contraction in guinea-pig trachea
Bertrand, C. [> >]
Tschirhart, Eric mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Landry, Y. [> >]
International Archives of Allergy and Applied Immunology
Yes (verified by ORBilu)
[en] Airway Resistance ; Pyrilamine ; Quercetin ; Quinolones ; Quinones ; Trachea ; drug effects ; physiopathology ; pharmacology ; immunology ; Ovalbumin ; Nedocromil ; Male ; Anaphylaxis ; Animals ; Benzoquinones ; Chromones ; Cromolyn Sodium ; Flavonols ; Guinea Pigs ; Immunoglobulin E ; Immunoglobulin G ; analogs and derivatives
[en] The effects of nedrocromil sodium and disodium cromoglycate were studied on the anaphylactic contraction of guinea-pig trachea in two models of active sensitization (IgE and IgG models). The influence of epithelial removal on the effects of nedocromil sodium and disodium cromoglycate was examined because several studies have shown that the epithelial layer can modulate agonist- or antigen-induced contractile responses. Disodium cromoglycate (10(-4) M) and nedocromil sodium (10(-4) M) provided significant protection against antigen-induced contractions of guinea-pig tracheal smooth muscle in the IgG model. But only nedocromil sodium had an effect at this concentration in the IgG model and was also effective at 10(-5) M in the epithelium-denuded tracheal strips. At this concentration, disodium cromoglycate lost its protective effect. Comparison with the results obtained with FPL-55712, AA-861 and mepyramine suggested that these drugs affect histamine and particularly leukotriene synthesis and/or release by mast cells or other immunocompetent cells. These findings indicate that nedocromil sodium inhibits the IgE- and IgG-related antigen-induced contraction in guinea-pig airways, whereas disodium cromoglycate inhibits only the IgG-related processes. This study supports the hypothesis that these drugs modulate antigen-induced mediator synthesis and/or release from immunocompetent cells.

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