Reference : Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylacti...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models
Bertrand, C. [> >]
Tschirhart, Eric mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Landry, Y. [> >]
Agents and Actions. Supplements
[en] Anaphylaxis ; physiology ; antagonists and inhibitors ; pharmacology ; physiopathology ; immunology ; Trachea ; Thromboxane A2 ; Thiazoles ; Platelet Activating Factor ; Muscle Contraction ; Indomethacin ; Immunoglobulin G ; Immunoglobulin E ; Guinea Pigs ; Glyceryl Ethers ; Antigens ; Animals ; drug effects
[en] In an IgE and an IgG model of anaphylaxis in the guinea pig, we investigated the role of prostanoids and PAF-acether in the tracheal response in vitro to immunochallenge. Indomethacin (10(-6) M) potentiated the antigen-induced contraction in both models suggesting the synthesis of relaxant prostaglandins during the anaphylactic phenomenon. UK-38,485 (10(-5) M), a thromboxane (TxA2) synthetase inhibitor, did not modify the tracheal response in the IgE model. In the IgG model, this drug reduced the response of the tracheal strips to antigen. Ro 19-3704 (10(-6) M) and BN 52021 (10(-5) M), two potent PAF antagonists, reduced antigen-induced contraction of the tracheal strips in the IgE model. These two drugs did not modify the contractile response in the IgG model. These results indicate that PAF-acether and TxA2 play a role in the IgE and IgG model of anaphylaxis, respectively.

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