Reference : Human umbilical cord blood monocyte-derived eosinophils produce superoxide but not ni...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human umbilical cord blood monocyte-derived eosinophils produce superoxide but not nitric oxide
Zardini, D. M. [> >]
Tschirhart, Eric mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Inflammation Research
Springer Science & Business Media B.V.
Yes (verified by ORBilu)
[en] biosynthesis ; Eosinophils ; Fetal Blood ; Humans ; Monocytes ; N-Formylmethionine Leucyl-Phenylalanine ; Nitric Oxide ; Nitric Oxide Synthase ; Nitric Oxide Synthase Type II ; Spectrometry, Fluorescence ; Superoxides ; enzymology ; metabolism ; cytology ; pharmacology ; blood ; Blotting, Western
[en] Both N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine, and 1-O-Alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine induced superoxide release in umbilical cord eosinophils, while no response was observed with lipopolysaccharide, interleukin-4 and/or interferon-gamma. Furthermore, upon activation with different inflammatory stimuli, neither induction of nitric oxide synthesis nor expression of the constitutive and/or inducible nitric oxide synthase were observed in these eosinophils derived in vitro. Human umbilical cord derived eosinophils are able to produce superoxide as peripheral blood eosinophils. Whether human peripheral eosinophils are capable of NO synthesis is still the subject of considerable debate, nevertheless, our results suggest that these in vitro derived eosinophils are not capable of nitric oxide synthesis.

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