No full text
Article (Scientific journals)
G-proteins as targets for non-immunological histamine releasers
Mousli, M.; Bueb, Jean-Luc; Rouot, B. et al.
1991In Agents and Actions, 33 (1-2), p. 81-3
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
drug effects; Bradykinin; GTP-Binding Proteins; Histamine Release; Male; Mast Cells; Peptides; Pertussis Toxin; Rats; Rats, Inbred Strains; Spermine; Substance P; Virulence Factors, Bordetella; Wasp Venoms; p-Methoxy-N-methylphenethylamine; pharmacology; physiology; Animals
Abstract :
[en] The molecular mechanism of action of several non-immunological histamine releasers has been investigated using pertussis toxin which interfers, via ADP-ribosylation, with some G-proteins. Pertussis toxin (100 ng/ml) inhibited histamine release induced by compound 48/80, substance P, mastoparan, peptide 401, bradykinin and spermine showing that a G-protein sensitive to pertussis toxin was involved in the non-immunological histamine release. All these compounds directly activate purified G-proteins. The sensitivity to pertussis toxin of this direct stimulatory effect was demonstrated for compound 48/80, mastoparan and substance P. Altogether these results suggest that a direct activation of G-protein might be the molecular mechanism of action of histamine secretagogues acting through a pertussis toxin sensitive G-protein and in this way mimic agonist-ligand receptor interaction.
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
UNILU:UL-ARTICLE-2008-203
Author, co-author :
Mousli, M.
Bueb, Jean-Luc ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Rouot, B.
Landry, Y.
Bronner, C.
Language :
English
Title :
G-proteins as targets for non-immunological histamine releasers
Publication date :
1991
Journal title :
Agents and Actions
ISSN :
0065-4299
Publisher :
Birkhauser Verlag, Basel, Switzerland
Volume :
33
Issue :
1-2
Pages :
81-3
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 09 September 2013

Statistics


Number of views
66 (1 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
20
Scopus citations®
without self-citations
19
WoS citations
 
18

Bibliography


Similar publications



Contact ORBilu