Reference : G-proteins as targets for non-immunological histamine releasers
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
G-proteins as targets for non-immunological histamine releasers
Mousli, M. [> >]
Bueb, Jean-Luc mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Rouot, B. [> >]
Landry, Y. [> >]
Bronner, C. [> >]
Agents and Actions
Birkhauser Verlag
Yes (verified by ORBilu)
[en] drug effects ; Bradykinin ; GTP-Binding Proteins ; Histamine Release ; Male ; Mast Cells ; Peptides ; Pertussis Toxin ; Rats ; Rats, Inbred Strains ; Spermine ; Substance P ; Virulence Factors, Bordetella ; Wasp Venoms ; p-Methoxy-N-methylphenethylamine ; pharmacology ; physiology ; Animals
[en] The molecular mechanism of action of several non-immunological histamine releasers has been investigated using pertussis toxin which interfers, via ADP-ribosylation, with some G-proteins. Pertussis toxin (100 ng/ml) inhibited histamine release induced by compound 48/80, substance P, mastoparan, peptide 401, bradykinin and spermine showing that a G-protein sensitive to pertussis toxin was involved in the non-immunological histamine release. All these compounds directly activate purified G-proteins. The sensitivity to pertussis toxin of this direct stimulatory effect was demonstrated for compound 48/80, mastoparan and substance P. Altogether these results suggest that a direct activation of G-protein might be the molecular mechanism of action of histamine secretagogues acting through a pertussis toxin sensitive G-protein and in this way mimic agonist-ligand receptor interaction.

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