Article (Scientific journals)
Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice.
Lessard-Beaudoin, Mélissa; Laroche, Mélissa; Demers, Marie-Josée et al.
2016In Biogerontology, 17 (5-6), p. 817-828
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Keywords :
Aging/metabolism; Animals; Brain/metabolism; Carrier Proteins/metabolism; Co-Repressor Proteins; Gene Expression Regulation, Developmental/physiology; Intracellular Signaling Peptides and Proteins/metabolism; Male; Mice; Mice, Inbred C57BL; Molecular Chaperones; Nuclear Proteins/metabolism; Organ Specificity/physiology; Viscera/metabolism; Aging; Brain region; C57BL/6 mice; Caspase; DAXX; Peripheral organs
Abstract :
[en] Death-associated protein 6 (DAXX) is a ubiquitous protein implicated in various cellular processes such as apoptosis, tumorigenesis, development and transcription. The role of DAXX is however ambiguous and many contradictory results regarding its function in apoptosis upon various cellular stresses are described in the literature. In order to have a better understanding of the role of DAXX throughout the entire organism under physiological stress conditions, we have characterized the mRNA levels, protein expression and the proteolytic processing of DAXX in the normal aging process in peripheral organs and brain regions in C57BL/6 male mice. Overall, Daxx mRNA expression decreases with aging in the liver, kidney, heart, cortex and cerebellum. In contrast, an increase is observed in the striatum. The protein expression of DAXX and of its proteolytic fragments increases with aging in the kidney, heart and cortex. In liver and spleen, no changes are observed while in the striatum and cerebellum, certain forms increase and others decrease with age, suggesting that the functions of DAXX may be cell type dependent. This study provides important details regarding the expression and post-translational modifications of DAXX in aging in the entire organism and provides reference data for the deregulation observed in age-associated diseases.
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Author, co-author :
Lessard-Beaudoin, Mélissa
Laroche, Mélissa
Demers, Marie-Josée
Duclos, Catherine
Denault, Jean-Bernard
Grenier, Guillaume
Riechers, Sean-Patrick Hermann  ;  Max Delbrück Centrum für Molekulare Medizin, Berlin-Buch, Neuroproteomics, 13125, Berlin, Germany.
Wanker, Erich E.
Graham, Rona K.
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Title :
Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice.
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Kluwer Academic Publishers, Netherlands
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