Reference : Secure and Distributed Assessment of Privacy-Preserving Releases of GWAS
Scientific congresses, symposiums and conference proceedings : Paper published in a journal
Engineering, computing & technology : Computer science
Security, Reliability and Trust
http://hdl.handle.net/10993/52124
Secure and Distributed Assessment of Privacy-Preserving Releases of GWAS
English
Pascoal, Túlio mailto [University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT) > CritiX >]
Decouchant, Jérémie mailto [TU Delft]
Volp, Marcus [University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT) > CritiX >]
Nov-2022
ACM/IFIP International Middleware Conference
Yes
International
23rd ACM/IFIP International Middleware Conference
7th – 11th November 2022
[en] Federated GWAS ; Privacy ; Honest-but-curious collusion
[en] Genome-wide association studies (GWAS) identify correlations between the genetic variants and an observable characteristic such as a disease. Previous works presented privacy-preserving distributed algorithms for a federation of genome data holders that spans multiple institutional and legislative domains to securely compute GWAS results. However, these algorithms have limited applicability, since they still require a centralized instance to decide whether GWAS results can be safely disclosed, which is in violation to privacy regulations, such as GDPR. In this work, we introduce GenDPR, a distributed middleware that leverages Trusted Execution Environments (TEEs) to securely determine a subset of the potential GWAS statistics that can be safely released. GenDPR achieves the same accuracy as centralized solutions, but requires transferring significantly less data because TEEs only exchange intermediary results but no genomes. Additionally, GenDPR can be configured to tolerate all-but-one honest-but-curious federation members colluding with the aim to expose genomes of correct members.
http://hdl.handle.net/10993/52124

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