Article (Scientific journals)
Historical Exposomics and High Resolution Mass Spectrometry
AURICH, Dagny; Miles, Owen; SCHYMANSKI, Emma
2021In Exposome, 00 (0)
Peer Reviewed verified by ORBi
 

Files


Full Text
1_HistoricalExposomicsReview.pdf
Author postprint (1.11 MB) Creative Commons License - Attribution
Free-access link https://academic.oup.com/exposome/advance-article/doi/10.1093/exposome/osab007/6491249?guestAccessKey=c75951aa-cf67-4f4a-9b1f-d865e96879ff
Download

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
exposome; high resolution mass spectrometry; history; health; cheminformatics; pollutants
Abstract :
[en] Awareness of the exposome and its influence on health has increased in the last decade. As past exposures can cause changes in human health many years later, delving into the past is relevant for both diagnostic and prevention purposes, but remains a challenging task. Lifestyle, diet, and socioeconomic information of the past should be well documented and compatible with modern data science methods. While chemical analysis nowadays makes use of high resolution mass spectrometry (HR-MS) for highly sensitive and comprehensive coverage of samples plus retrospective analysis, these data archives are in the very early stages. Since past measurements are often only available for a limited set of chemicals, adding to this knowledge requires careful selection of sample types and sampling sites, which may not always be available. The choice of analytes and analytical methods should be suitable for the study question —which is not always clear in advance in exposomics. Data interpretation and the use of appropriate databases are indispensable for a proper exposure assessment, and as databases and knowledge grow, re-analysis of physically or digitally archived samples could enable “continuous monitoring” efforts. This review focuses on the chemical analytical approaches necessary to capture the complexity of the historical exposome. Various sample types, analytes as well as analyses and data interpretation methods are discussed in relation to chemical exposures, while the connection to health remains in focus. It ends with perspectives and challenges in assessing the historical exposome, discussing how we can “learn from the past” to build a better future.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Environmental Cheminformatics (Schymanski Group)
Disciplines :
Chemistry
Author, co-author :
AURICH, Dagny  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Environmental Cheminformatics
Miles, Owen;  Luxembourg Institute of Science & Technology - LIST
SCHYMANSKI, Emma  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Environmental Cheminformatics
External co-authors :
no
Language :
English
Title :
Historical Exposomics and High Resolution Mass Spectrometry
Publication date :
31 December 2021
Journal title :
Exposome
eISSN :
2635-2265
Publisher :
Oxford University Press
Volume :
00
Issue :
0
Peer reviewed :
Peer Reviewed verified by ORBi
FnR Project :
FNR12341006 - Environmental Cheminformatics To Identify Unknown Chemicals And Their Effects, 2018 (01/10/2018-30/09/2023) - Emma Schymanski
Name of the research project :
LuxTIME (Audacity-2019)
Funders :
University of Luxembourg - UL, Institute for Advanced Studies
FNR - Fonds National de la Recherche [LU]
Available on ORBilu :
since 06 January 2022

Statistics


Number of views
126 (40 by Unilu)
Number of downloads
7 (2 by Unilu)

OpenCitations
 
4

Bibliography


Similar publications



Contact ORBilu