Reference : Dissociated face- and word-selective intracerebral responses in the human ventral occ...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Dissociated face- and word-selective intracerebral responses in the human ventral occipito-temporal cortex.
Hagen, Simen [> >]
Lochy, Aliette mailto [University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS)]
Jacques, Corentin [> >]
Maillard, Louis [> >]
Colnat-Coulbois, Sophie [> >]
Jonas, Jacques [> >]
Rossion, Bruno [> >]
Brain Structure & Function
Yes (verified by ORBilu)
[en] Face categorization ; Word categorization ; Frequency-tagging ; SEEG ; Fusiform gyrus ; Anterior temporal lobe
[en] The extent to which faces and written words share neural circuitry in the human brain is actively debated. Here, we compare face-selective and word-selective responses in a large group of patients (N = 37) implanted with intracerebral electrodes in the ventral occipito-temporal cortex (VOTC). Both face-selective (i.e., significantly different responses to faces vs. non-face visual objects) and word-selective (i.e., significantly different responses to words vs. pseudofonts) neural activity is isolated with frequency-tagging. Critically, this sensitive approach allows to objectively quantify category-selective neural responses and disentangle them from general visual responses. About 70% of significant electrode contacts show either face-selectivity or word-selectivity only, with the expected right and left hemispheric dominance, respectively. Spatial dissociations are also found within core regions of face and word processing, with a medio-lateral dissociation in the fusiform gyrus (FG) and surrounding sulci, respectively. In the 30% of overlapping face- and word-selective contacts across the VOTC or in the FG and surrounding sulci, between-category-selective amplitudes (faces vs. words) show no-to-weak correlations, despite strong correlations in both the within-category-selective amplitudes (face–face, word–word) and the general visual responses to words and faces. Overall, these observations support the view that category-selective circuitry for faces and written words is largely dissociated in the human adult VOTC.Supplementary Information: The online version contains supplementary material available at 10.1007/s00429-021-02350-4.
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