| Reference : Quantifying activities of daily living impairment in Parkinson’s disease using the Fu... |
| Scientific journals : Article | |||
| Social & behavioral sciences, psychology : Neurosciences & behavior | |||
| http://hdl.handle.net/10993/48779 | |||
| Quantifying activities of daily living impairment in Parkinson’s disease using the Functional Activities Questionnaire | |
| English | |
| Becker, Sara [German Center for Neurodegenerative Diseases > Department of Neurodegenerative Diseases,] | |
Pauly, Claire  [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience >] | |
| Lawton, Michael [University of Bristol > Department of Population Health Science] | |
| Hipp, Géraldine [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >] | |
| Bowring, Francesca [University of Oxford > Nuffield Department of Clinical Neurosciences] | |
| Sulzer, Patricia [Hertie Institute for Clinical Brain Research > Department of Neurodegenerative Diseases] | |
| Hu, Michele [University of Oxford > Nuffield Department of Clinical Neurosciences] | |
| Krüger, Rejko [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience >] | |
| Gasser, Thomas [Hertie Institute for Clinical Brain Research > Department of Neurodegenerative Diseases] | |
| Liepelt-Scarfone, Inga [Hertie Institute for Clinical Brain Research > Department of Neurodegenerative Diseases] | |
| 2021 | |
| Neurological Sciences | |
| Springer | |
| Yes (verified by ORBilu) | |
| International | |
| 1590-1874 | |
| 1590-3478 | |
| New York | |
| Germany | |
| [en] Cognitive dysfunction ; Mild cognitive impairment ; Neuropsychological tests | |
| [en] Objective Cognitive-driven activity of daily living (ADL) impairment in Parkinson’s disease (PD) is increasingly discussed
as prodromal marker for dementia. Diagnostic properties of assessments for this specifc ADL impairment are sparsely investigated in PD. The ability of the Functional Activities Questionnaire (FAQ) for diferentiating between PD patients with normal cognition and with mild cognitive impairment (PD-MCI), according to informant and self-reports, was examined. Global cognitive function in groups with and without mild ADL impairment was compared according to diferent cut-ofs. Methods Multicenter data of 589 patients of an international cohort (CENTRE-PD) were analyzed. Analyses were run separately for informant-rated and self-rated FAQ. Receiver operating characteristic (ROC) analysis was conducted to defne the optimal FAQ cut-of for PD-MCI (≥1), and groups were additionally split according to reported FAQ cut-ofs for PD-MCI in the literature (≥3,≥5). Binary logistic regressions examined the efect of the Montreal Cognitive Assessment (MoCA) score in PD patients with and without mild ADL impairment. Results Two hundred and twenty-fve (38.2%) patients were classifed as PD-MCI. For all three cut-of values, sensitivity was moderate to low (<0.55), but specifcity was moderately high (>0.54) with a tendency of higher values for self-reported defcits. For the self-report, the cut-of≥3 showed a signifcant efect of the MoCA (B= −0.31, p=0.003), where FAQ≥3 patients had worse cognition. No efect for group diferences based on informant ratings was detected. Conclusion Our data argue that self-reported ADL impairments assessed by the FAQ show a relation to the severity of cognitive impairment in PD. | |
| http://hdl.handle.net/10993/48779 |
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