Article (Scientific journals)
Resources for Systems Genetics.
Williams, Robert W.; Williams, Evan
2017In Methods in Molecular Biology, 1488, p. 3-29
Peer Reviewed verified by ORBi
 

Files


Full Text
A_CHAPTER_FINAL.pdf
Publisher postprint (429.07 kB)
Request a copy

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
Animals; Breeding; Chromosome Mapping/methods; Crosses, Genetic; Genetic Techniques; Genetics, Population/methods; Genomics/methods; Genotype; Humans; Hybridization, Genetic; Inbreeding; Mutation; Quantitative Trait Loci; Research Design; Collaborative Cross (CC); Congenic lines; Consomic and chromosome substitution lines; Diversity outcross (DO); Gene-by-environment interactions (G x E); Genetic reference population (GRP); Heterogeneous stock (HS); Hybrid diversity panel (HDP); RI intercross (RIX) and RI backcross (RIB) progeny; Recombinant congenic strains; Recombinant inbred (RI); Reduced complexity cross (RCC)
Abstract :
[en] A key characteristic of systems genetics is its reliance on populations that vary to a greater or lesser degree in genetic complexity-from highly admixed populations such as the Collaborative Cross and Diversity Outcross to relatively simple crosses such as sets of consomic strains and reduced complexity crosses. This protocol is intended to help investigators make more informed decisions about choices of resources given different types of questions. We consider factors such as costs, availability, and ease of breeding for common scenarios. In general, we recommend using complementary resources and minimizing depth of resampling of any given genome or strain.
Disciplines :
Genetics & genetic processes
Author, co-author :
Williams, Robert W.
Williams, Evan  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
yes
Language :
English
Title :
Resources for Systems Genetics.
Publication date :
2017
Journal title :
Methods in Molecular Biology
ISSN :
1940-6029
Publisher :
Humana Press, Clifton, United States - New Jersey
Volume :
1488
Pages :
3-29
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 11 May 2020

Statistics


Number of views
45 (2 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
28
Scopus citations®
without self-citations
24
OpenCitations
 
21

Bibliography


Similar publications



Contact ORBilu