Article (Scientific journals)
A general strategy for cellular reprogramming: the importance of transcription factor cross-repression
Crespo, Isaac; del Sol Mesa, Antonio
2013In Stem Cells
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Keywords :
Cellular reprogramming; Differentiation; cross-antagonistic
Abstract :
[en] Transcription factor cross-repression is an important concept in cellular differentiation. A bistable toggle switch constitutes a molecular mechanism that determines cellular commitment and provides stability to transcriptional programs of binary cell fate choices. Experiments support that perturbations of these toggle switches can interconvert these binary cell fate choices, suggesting potential reprogramming strategies. However, more complex types of cellular transitions could involve perturbations of combinations of different types of multistable motifs. Here we introduce a method that generalizes the concept of transcription factor cross-repression to systematically predict sets of genes, whose perturbations induce cellular transitions between any given pair of cell types. Furthermore, to our knowledge, this is the first method that systematically makes these predictions without prior knowledge of potential candidate genes and pathways involved, providing guidance on systems where little is known. Given the increasing interest of cellular reprogramming in medicine and basic research, our method represents a useful computational methodology to assist researchers in the field in designing experimental strategies.
Research center :
LCSB
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Crespo, Isaac ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
del Sol Mesa, Antonio ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Language :
English
Title :
A general strategy for cellular reprogramming: the importance of transcription factor cross-repression
Publication date :
2013
Journal title :
Stem Cells
ISSN :
1549-4918
Publisher :
Wiley, Malden, United States - Massachusetts
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 22 July 2013

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