Reference : JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.
Stelzer, Sandra [> >]
Ebnet, Klaus [> >]
Schwamborn, Jens Christian mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
BMC Neuroscience
Yes (verified by ORBilu)
[en] Aging ; Animals ; Antigens/metabolism ; Astrocytes/cytology/metabolism ; Brain/cytology/metabolism ; Cell Adhesion Molecules/metabolism ; Cell Membrane/metabolism ; Cell Proliferation ; Mice ; Mitosis ; Neuroglia/cytology/metabolism ; Neurons/cytology/metabolism ; Oligodendroglia/cytology/metabolism ; Proteoglycans/metabolism ; Receptors, Cell Surface/metabolism ; Stem Cell Niche/cytology/metabolism ; Stem Cells/cytology/metabolism
[en] BACKGROUND: Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. RESULTS: So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. CONCLUSIONS: Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain.

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