Article (Scientific journals)
JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.
Stelzer, Sandra; Ebnet, Klaus; Schwamborn, Jens Christian
2010In BMC Neuroscience, 11, p. 27
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Keywords :
Aging; Animals; Antigens/metabolism; Astrocytes/cytology/metabolism; Brain/cytology/metabolism; Cell Adhesion Molecules/metabolism; Cell Membrane/metabolism; Cell Proliferation; Mice; Mitosis; Neuroglia/cytology/metabolism; Neurons/cytology/metabolism; Oligodendroglia/cytology/metabolism; Proteoglycans/metabolism; Receptors, Cell Surface/metabolism; Stem Cell Niche/cytology/metabolism; Stem Cells/cytology/metabolism
Abstract :
[en] BACKGROUND: Junctional adhesion molecule-A (JAM-A) is an adhesive protein expressed in various cell types. JAM-A localizes to the tight junctions between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesion and to the control of paracellular permeability. RESULTS: So far, the expression pattern of JAM-A has not been described in detail for the different cell types of the adult brain. Here we show that a subset of proliferating cells in the adult mouse brain express JAM-A. We further clarify that these cells belong to the lineage of NG2-glia cells. Although these mitotic NG2-glia cells express JAM-A, the protein never shows a polarized subcellular distribution. Also non-mitotic NG2-glia cells express JAM-A in a non-polarized pattern on their surface. CONCLUSIONS: Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Stelzer, Sandra
Ebnet, Klaus
Schwamborn, Jens Christian ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
Title :
JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.
Publication date :
Journal title :
BMC Neuroscience
Publisher :
BioMed Central, United Kingdom
Volume :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
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