Article (Scientific journals)
Cellular organization of adult neurogenesis in the Common Marmoset.
Bunk, Eva C.; Stelzer, Sandra; Hermann, Sven et al.
2011In Aging Cell, 10 (1), p. 28-38
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Keywords :
Adult; Aging/physiology; Animals; Autoradiography; Biological Markers/analysis; Callithrix/anatomy & histology/physiology; Cell Count; Cell Movement/physiology; Cell Proliferation; Dentate Gyrus/anatomy & histology/physiology; Female; Humans; Immunohistochemistry; Lateral Ventricles/anatomy & histology/physiology; Male; Mice; Neural Stem Cells/cytology/physiology; Neurogenesis/physiology; Neurons/cytology/physiology; Rats
Abstract :
[en] Adult neurogenesis within the subgranular zone (SGZ) of the hippocampal dentate gyrus and the subventricular zone (SVZ) of the lateral ventricle (LV) has been most intensely studied within the brains of rodents such as mice and rats. However, little is known about the cell types and processes involved in adult neurogenesis within primates such as the common marmoset (Callithrix jacchus). Moreover, substantial differences seem to exist between the neurogenic niche of the LV between rodents and humans. Here, we set out to use immunohistochemical and autogradiographic analysis to characterize the anatomy of the neurogenic niches and the expression of cell type-specific markers in those niches in the adult common marmoset brain. Moreover, we demonstrate significant differences in the activity of neurogenesis in the adult marmoset brain compared to the adult mouse brain. Finally, we provide evidence for ongoing proliferation of neuroblasts within both the SGZ and SVZ of the adult brain and further show that the age-dependent decline of neurogenesis in the hippocampus is associated with a decrease in neuroblast cells.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Bunk, Eva C.
Stelzer, Sandra
Hermann, Sven
Schafers, Michael
Schlatt, Stefan
Schwamborn, Jens Christian ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
English
Title :
Cellular organization of adult neurogenesis in the Common Marmoset.
Publication date :
2011
Journal title :
Aging Cell
ISSN :
1474-9728
Publisher :
Wiley-Blackwell, United Kingdom
Volume :
10
Issue :
1
Pages :
28-38
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 21 June 2013

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