Article (Scientific journals)
Platelet activation and aggregation promote lung inflammation and influenza virus pathogenesis.
Le, Vuong Ba; Schneider, Jochen; Boergeling, Yvonne et al.
2015In American Journal of Respiratory and Critical Care Medicine, 191 (7), p. 804-19
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Keywords :
Animals; Anti-Inflammatory Agents/therapeutic use; Antiviral Agents/therapeutic use; Disease Models, Animal; Female; Humans; Influenza, Human/complications/drug therapy/physiopathology/virology; Male; Mice; Mice, Inbred BALB C; Orthomyxoviridae/drug effects/pathogenicity; Platelet Activation/physiology; Platelet Aggregation/physiology; Pneumonia/complications/drug therapy/physiopathology; flu pathogenesis; lung injury; novel drugs; platelets; pneumonia
Abstract :
[en] RATIONALE: The hallmark of severe influenza virus infection is excessive inflammation of the lungs. Platelets are activated during influenza, but their role in influenza virus pathogenesis and inflammatory responses is unknown. OBJECTIVES: To determine the role of platelets during influenza A virus infections and propose new therapeutics against influenza. METHODS: We used targeted gene deletion approaches and pharmacologic interventions to investigate the role of platelets during influenza virus infection in mice. MEASUREMENTS AND MAIN RESULTS: Lungs of infected mice were massively infiltrated by aggregates of activated platelets. Platelet activation promoted influenza A virus pathogenesis. Activating protease-activated receptor 4, a platelet receptor for thrombin that is crucial for platelet activation, exacerbated influenza-induced acute lung injury and death. In contrast, deficiency in the major platelet receptor glycoprotein IIIa protected mice from death caused by influenza viruses, and treating the mice with a specific glycoprotein IIb/IIIa antagonist, eptifibatide, had the same effect. Interestingly, mice treated with other antiplatelet compounds (antagonists of protease-activated receptor 4, MRS 2179, and clopidogrel) were also protected from severe lung injury and lethal infections induced by several influenza strains. CONCLUSIONS: The intricate relationship between hemostasis and inflammation has major consequences in influenza virus pathogenesis, and antiplatelet drugs might be explored to develop new antiinflammatory treatment against influenza virus infections.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Medical Translational Research (J. Schneider Group)
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Le, Vuong Ba
Schneider, Jochen ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Boergeling, Yvonne
Berri, Fatma
Ducatez, Mariette
Guerin, Jean-Luc
Adrian, Iris
Errazuriz-Cerda, Elisabeth
Frasquilho, Sonia
Antunes, Laurent
Lina, Bruno
Bordet, Jean-Claude
Jandrot-Perrus, Martine
Ludwig, Stephan
Riteau, Beatrice
More authors (5 more) Less
External co-authors :
yes
Language :
English
Title :
Platelet activation and aggregation promote lung inflammation and influenza virus pathogenesis.
Publication date :
2015
Journal title :
American Journal of Respiratory and Critical Care Medicine
ISSN :
1535-4970
Publisher :
American Thoracic Society, United States - New York
Volume :
191
Issue :
7
Pages :
804-19
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 16 May 2016

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