Article (Scientific journals)
MiRNAs and neural stem cells: a team to treat Parkinson's disease?
Palm, Thomas; Bahnassawy, Lamia A; Schwamborn, Jens Christian
2012In RNA Biology, 9 (6), p. 720-30
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Keywords :
Animals; Biological Markers/blood; Cell Differentiation; Humans; MicroRNAs/blood/genetics/physiology; Neural Stem Cells/physiology/transplantation; Parkinson Disease/blood/pathology/therapy; RNA Interference; alpha-Synuclein/genetics/metabolism
Abstract :
[en] Parkinson's disease (PD) is a common neurodegenerative disorder with no proven neuroprotective or neurorestorative therapies. During disease progression, degeneration of dopaminergic neurons of the central nervous system occurs. Therefore, therapies that either aim on the inhibition of this degeneration or on the replacement of the degenerated neurons are needed. On the one hand, arrest of degeneration might be achievable through specific inhibition of disease associated genes like alpha-Synuclein or Leucine rich repeat kinase 2 (LRRK2). On the other hand, based on neural stem cells that bear the ability to generate new dopaminergic neurons, replacement of degenerated cells could be accomplished. Since both approaches can be regulated by micro-RNAs, these molecules have an enormous therapeutic potential. In this review, we will focus on the neurobiological and neurodegenerative implications of miRNAs and highlight their role in stem cell fate decisions. Finally, we will discuss their potential as therapeutic agents and targets for Parkinson's disease.
Disciplines :
Genetics & genetic processes
Author, co-author :
Palm, Thomas
Bahnassawy, Lamia A
Schwamborn, Jens Christian ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
English
Title :
MiRNAs and neural stem cells: a team to treat Parkinson's disease?
Publication date :
2012
Journal title :
RNA Biology
ISSN :
1555-8584
Publisher :
Landes Bioscience, United States
Volume :
9
Issue :
6
Pages :
720-30
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 21 June 2013

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