The nucleotide excision repair (NER) system of Helicobacter pylori: Roles of NER components in mutation prevention and chromosomal import patterns after natural transformation

Moccia, Claudia; Kulick, Stefan; Krebes, Juliane; Didelot, Xavier; Kraft, Christian; Bahlawane, Christelle; Suerbaum, Sebastian

doi:10.1186/1471-2180-12-67

Reference : The nucleotide excision repair (NER) system of Helicobacter pylori: Roles of NER comp...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/10993/26352

Title :	The nucleotide excision repair (NER) system of Helicobacter pylori: Roles of NER components in mutation prevention and chromosomal import patterns after natural transformation
Language :	English
Author, co-author :	Moccia, Claudia* [Hannover Medical School, Germany > Institute for Medical Microbiology and Hospital Epidemiology]
	Kulick, Stefan* [Hannover Medical School, Germany > Institute for Medical Microbiology and Hospital Epidemiology]
	Krebes, Juliane* [Hannover Medical School, Germany > Institute for Medical Microbiology and Hospital Epidemiology]
	Didelot, Xavier [Oxford University > Department of Statistics]
	Kraft, Christian [Hannover Medical School, Germany > Institute for Medical Microbiology and Hospital Epidemiology]
	Bahlawane, Christelle [hannover Medical School]
	Suerbaum, Sebastian [Hannover Medical School, Germany > Institute for Medical Microbiology and Hospital Epidemiology]
	* These authors have contributed equally to this work.
Publication date :	2012
Journal title :	BMC Microbiology
Publisher :	BioMed Central
Volume :	6
Issue/season :	12
Pages :	67
Peer reviewed :	Yes (verified by ORBi^lu)
Audience :	International
e-ISSN :	1471-2180
Abstract :	[en] Extensive genetic diversity and rapid allelic diversification are characteristics of the human gastric pathogen Helicobacter pylori, and are believed to contribute to its ability to cause chronic infections. Both a high mutation rate and frequent imports of short fragments of exogenous DNA during mixed infections play important roles in generating this allelic diversity. In this study, we used a genetic approach to investigate the roles of nucleotide excision repair (NER) pathway components in H. pylori mutation and recombination.
Permalink :	http://hdl.handle.net/10993/26352
DOI :	10.1186/1471-2180-12-67

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