Reference : The nucleotide excision repair (NER) system of Helicobacter pylori: Roles of NER comp...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/26352
The nucleotide excision repair (NER) system of Helicobacter pylori: Roles of NER components in mutation prevention and chromosomal import patterns after natural transformation
English
Moccia, Claudia*[Hannover Medical School, Germany > Institute for Medical Microbiology and Hospital Epidemiology]
Kulick, Stefan*[Hannover Medical School, Germany > Institute for Medical Microbiology and Hospital Epidemiology]
Krebes, Juliane*[Hannover Medical School, Germany > Institute for Medical Microbiology and Hospital Epidemiology]
Didelot, Xavier[Oxford University > Department of Statistics]
Kraft, Christian[Hannover Medical School, Germany > Institute for Medical Microbiology and Hospital Epidemiology]
[en] Extensive genetic diversity and rapid allelic diversification are characteristics of the human gastric pathogen Helicobacter pylori, and are believed to contribute to its ability to cause chronic infections. Both a high mutation rate and frequent imports of short fragments of exogenous DNA during mixed infections play important roles in generating this allelic diversity. In this study, we used a genetic approach to investigate the roles of nucleotide excision repair (NER) pathway components in H. pylori mutation and recombination.