Article (Scientific journals)
Mitochondrial phylogenomics of modern and ancient equids.
Vilstrup, Julia T.; Seguin-Orlando, Andaine; Stiller, Mathias et al.
2013In PLoS ONE, 8 (2), p. 55950
Peer Reviewed verified by ORBi


Full Text
Publisher postprint (395.07 kB)
Request a copy

All documents in ORBilu are protected by a user license.

Send to


Keywords :
Animals; Bayes Theorem; Fossils; Genome, Mitochondrial/genetics; Genomics; Horses/genetics; Phylogeny; Selection, Genetic/genetics; Time Factors
Abstract :
[en] The genus Equus is richly represented in the fossil record, yet our understanding of taxonomic relationships within this genus remains limited. To estimate the phylogenetic relationships among modern horses, zebras, asses and donkeys, we generated the first data set including complete mitochondrial sequences from all seven extant lineages within the genus Equus. Bayesian and Maximum Likelihood phylogenetic inference confirms that zebras are monophyletic within the genus, and the Plains and Grevy's zebras form a well-supported monophyletic group. Using ancient DNA techniques, we further characterize the complete mitochondrial genomes of three extinct equid lineages (the New World stilt-legged horses, NWSLH; the subgenus Sussemionus; and the Quagga, Equus quagga quagga). Comparisons with extant taxa confirm the NWSLH as being part of the caballines, and the Quagga and Plains zebras as being conspecific. However, the evolutionary relationships among the non-caballine lineages, including the now-extinct subgenus Sussemionus, remain unresolved, most likely due to extremely rapid radiation within this group. The closest living outgroups (rhinos and tapirs) were found to be too phylogenetically distant to calibrate reliable molecular clocks. Additional mitochondrial genome sequence data, including radiocarbon dated ancient equids, will be required before revisiting the exact timing of the lineage radiation leading up to modern equids, which for now were found to have possibly shared a common ancestor as far as up to 4 Million years ago (Mya).
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Vilstrup, Julia T.
Seguin-Orlando, Andaine
Stiller, Mathias
Ginolhac, Aurélien  ;  University of Copenhagen > Centre for Geogenetics
Raghavan, Maanasa
Nielsen, Sandra C. A.
Weinstock, Jacobo
Froese, Duane
Vasiliev, Sergei K.
Ovodov, Nikolai D.
Clary, Joel
Helgen, Kristofer M.
Fleischer, Robert C.
Cooper, Alan
Shapiro, Beth
Orlando, Ludovic
More authors (6 more) Less
External co-authors :
Language :
Title :
Mitochondrial phylogenomics of modern and ancient equids.
Publication date :
Journal title :
Publisher :
Public Library of Science, United States - California
Volume :
Issue :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 30 March 2016


Number of views
84 (0 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
Scopus citations®
without self-citations
WoS citations


Similar publications

Contact ORBilu