Reference : Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxog... |
Scientific journals : Article | |||
Life sciences : Biochemistry, biophysics & molecular biology Physical, chemical, mathematical & earth Sciences : Chemistry | |||
http://hdl.handle.net/10993/26336 | |||
Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. | |
English | |
Thinnes, Cyrille [University of Oxford > Department of Chemistry] | |
Tumber, A. [> >] | |
Yapp, C. [> >] | |
Scozzafava, G. [> >] | |
Yeh, T. [> >] | |
Chan, M. C. [> >] | |
Tran, T. A. [> >] | |
Hsu, K. [> >] | |
Tarhonskaya, H. [> >] | |
Walport, L. J. [> >] | |
Wilkins, S. E. [> >] | |
Martinez, E. D. [> >] | |
Muller, S. [> >] | |
Pugh, C. W. [> >] | |
Ratcliffe, P. J. [> >] | |
Brennan, P. E. [> >] | |
Kawamura, A. [> >] | |
Schofield, C. J. [> >] | |
2015 | |
Chemical Communications | |
51 | |
84 | |
15458-61 | |
Yes (verified by ORBilu) | |
International | |
1359-7345 | |
1364-548X | |
England | |
[en] There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in functional and target validation studies. The 3-component Betti reaction enables efficient one-step C-7 functionalisation of modified 8-hydroxyquinolines (8HQs) to produce cell-active inhibitors of KDM4 histone demethylases and other 2OG oxygenases; the work exemplifies how a template-based metallo-enzyme inhibitor approach can be used to give biologically active compounds. | |
http://hdl.handle.net/10993/26336 | |
10.1039/c5cc06095h |
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