| Reference : Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxog... |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology Physical, chemical, mathematical & earth Sciences : Chemistry | |||
| http://hdl.handle.net/10993/26336 | |||
| Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. | |
| English | |
| Thinnes, Cyrille [University of Oxford > Department of Chemistry] | |
| Tumber, A. [> >] | |
| Yapp, C. [> >] | |
| Scozzafava, G. [> >] | |
| Yeh, T. [> >] | |
| Chan, M. C. [> >] | |
| Tran, T. A. [> >] | |
| Hsu, K. [> >] | |
| Tarhonskaya, H. [> >] | |
| Walport, L. J. [> >] | |
| Wilkins, S. E. [> >] | |
| Martinez, E. D. [> >] | |
| Muller, S. [> >] | |
| Pugh, C. W. [> >] | |
| Ratcliffe, P. J. [> >] | |
| Brennan, P. E. [> >] | |
| Kawamura, A. [> >] | |
| Schofield, C. J. [> >] | |
| 2015 | |
| Chemical Communications | |
| 51 | |
| 84 | |
| 15458-61 | |
| Yes (verified by ORBilu) | |
| International | |
| 1359-7345 | |
| 1364-548X | |
| England | |
| [en] There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in functional and target validation studies. The 3-component Betti reaction enables efficient one-step C-7 functionalisation of modified 8-hydroxyquinolines (8HQs) to produce cell-active inhibitors of KDM4 histone demethylases and other 2OG oxygenases; the work exemplifies how a template-based metallo-enzyme inhibitor approach can be used to give biologically active compounds. | |
| http://hdl.handle.net/10993/26336 | |
| 10.1039/c5cc06095h |
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