Static Output Feedback H-infinity Control for a Fractional-Order Glucose-Insulin System

This paper presents the H∞ static output feedback control of nonlinear fractional-order systems.
Based on the extended bounded real lemma, the H∞ control is formulated and sufficient conditions are derived in terms of linear matrix inequalities (LMIs) formulation by using the fractional Lyapunov direct method where the fractional-order α belongs to 0 < α < 1. The control approach is finally applied to the regulation of the glucose level in diabetes type 1 treatment. Therefore, it is attempted to incorporate fractional-order into the mathematical minimal model of glucose-insulin system dynamics and it is still an interesting challenge to show, how the order of a fractional differential system affects the dynamics of the system in the presence of meal disturbance. Numerical simulations are carried out to illustrate our proposed results and show that the nonlinear fractional-order glucose-insulin systems
are, at least, as stable as their integer-order counterpart in the presence of exogenous glucose infusion or meal disturbance.