Reference : Thermodynamics of accuracy in kinetic proofreading: dissipation and efficiency trade-offs
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Physics
Thermodynamics of accuracy in kinetic proofreading: dissipation and efficiency trade-offs
Rao, Riccardo mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit >]
Peliti, Luca mailto [Institute for Advanced Study > Simons Center for Systems Biology]
Journal of Statistical Mechanics: Theory and Experiment
Institute of Physics Publishing
Yes (verified by ORBilu)
[en] The high accuracy exhibited by biological information transcription
processes is due to kinetic proofreading, i.e. by a mechanism which reduces the
error rate of the information-handling process by driving it out of equilibrium.
We provide a consistent thermodynamic description of enzyme-assisted assembly
processes involving competing substrates, in a master equation framework. We
introduce and evaluate a measure of the efficiency based on rigorous non-
equilibrium inequalities. The performance of several proofreading models are thus
analyzed and the related time, dissipation and efficiency versus error trade-offs
exhibited for different discrimination regimes. We finally introduce and analyse
in the same framework a simple model which takes into account correlations
between consecutive enzyme-assisted assembly steps. This work highlights the
relevance of the distinction between energetic and kinetic discrimination regimes
in enzyme-substrate interactions.

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