Article (Scientific journals)
Thermodynamics of accuracy in kinetic proofreading: dissipation and efficiency trade-offs
Rao, Riccardo; Peliti, Luca
2015In Journal of Statistical Mechanics: Theory and Experiment, p. 06001
Peer Reviewed verified by ORBi
 

Files


Full Text
Rao et al. (2015a) - Thermodynamics of accuracy in kinetic proofreading: Dissipation and efficiency trade-offs.pdf
Author preprint (342.35 kB)
Download

All documents in ORBilu are protected by a user license.

Send to



Details



Abstract :
[en] The high accuracy exhibited by biological information transcription processes is due to kinetic proofreading, i.e. by a mechanism which reduces the error rate of the information-handling process by driving it out of equilibrium. We provide a consistent thermodynamic description of enzyme-assisted assembly processes involving competing substrates, in a master equation framework. We introduce and evaluate a measure of the efficiency based on rigorous non- equilibrium inequalities. The performance of several proofreading models are thus analyzed and the related time, dissipation and efficiency versus error trade-offs exhibited for different discrimination regimes. We finally introduce and analyse in the same framework a simple model which takes into account correlations between consecutive enzyme-assisted assembly steps. This work highlights the relevance of the distinction between energetic and kinetic discrimination regimes in enzyme-substrate interactions.
Disciplines :
Physics
Author, co-author :
Rao, Riccardo ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit
Peliti, Luca;  Institute for Advanced Study > Simons Center for Systems Biology
External co-authors :
yes
Language :
English
Title :
Thermodynamics of accuracy in kinetic proofreading: dissipation and efficiency trade-offs
Publication date :
June 2015
Journal title :
Journal of Statistical Mechanics: Theory and Experiment
ISSN :
1742-5468
Publisher :
Institute of Physics Publishing, Bristol, United Kingdom
Pages :
P06001
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 16 January 2016

Statistics


Number of views
115 (12 by Unilu)
Number of downloads
90 (6 by Unilu)

Scopus citations®
 
29
Scopus citations®
without self-citations
24
WoS citations
 
29

Bibliography


Similar publications



Contact ORBilu