Article (Scientific journals)
Systems approaches to modelling pathways and networks
Pfau, Thomas; Christian, Nils; Ebenhöh, Oliver
2011In Briefings in Functional Genomics, 10 (5), p. 266-279
Peer reviewed


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This is a pre-copyedited, author-produced PDF of an article accepted for publication in Briefings in functional Genomics following peer review. The version of record, Systems approaches to modelling pathways and networks, Briefings in Functional Genomics (2011) 10 (5): 266-279, doi:10.1093/bfgp/elr022 is available online at
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Keywords :
genome-scale networks; systems biology; constraint based modelling; mathematical Modelling; metabolism; dynamic systems
Abstract :
[en] It has become commonly accepted that systems approaches to biology are of outstanding importance to gain understanding from the vast amount of data which is presently being generated by advancing high-throughput technologies. The diversity of methods to model pathways and networks has significantly expanded over the past two decades. Modern and traditional approaches are equally important and recent activities aim at integrating the advantages of both. While traditional methods, based on differential equations, are useful to study the dynamics of small systems, modern constraint-based models can be applied to genome-scale systems, but are not able to capture dynamic features. Integrating different approaches is important to develop consistent theoretical descriptions encompassing various scales of biological information. The rapid progress of the field of theoretical systems biology, however, demonstrates how our fundamental theoretical understanding of biology is gaining momentum. The scientific community has apparently accepted the challenge to truly understand the principles of life.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Life sciences: Multidisciplinary, general & others
Author, co-author :
Pfau, Thomas ;  University of Aberdeen > Institute of Complex Systems and Mathematical Biology
Christian, Nils ;  University of Aberdeen > Institute of Complex Systems and Mathematical Biology
Ebenhöh, Oliver;  University of Aberdeen > Institute of Complex Systems and Mathematical Biology
Language :
Title :
Systems approaches to modelling pathways and networks
Alternative titles :
[en] Systems approaches to modelling pathways and networks
Publication date :
Journal title :
Briefings in Functional Genomics
Publisher :
Oxford University Press, Oxford, United Kingdom
Volume :
Issue :
Pages :
Peer reviewed :
Peer reviewed
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