Reference : The role of synphilin-1 in synaptic function and protein degradation. |
Scientific journals : Article | |||
Life sciences : Genetics & genetic processes | |||
http://hdl.handle.net/10993/17139 | |||
The role of synphilin-1 in synaptic function and protein degradation. | |
English | |
Krüger, Rejko ![]() | |
2004 | |
Cell and Tissue Research | |
318 | |
1 | |
195-9 | |
Yes | |
0302-766X | |
Germany | |
[en] Carrier Proteins/genetics/metabolism ; Humans ; Nerve Tissue Proteins/genetics/metabolism ; Parkinson Disease/genetics/physiopathology ; Synapses/physiology | |
[en] The name synphilin-1 comes from its identification as an alpha-synuclein-interacting protein (SNCAIP) in yeast two-hybrid screens. Since alpha-synuclein ( PARK1) was the first gene identified as causing inherited forms of Parkinson's disease (PD), synphilin-1 was quickly implicated in neurodegeneration in PD. Recently, the first genetic evidence for the direct contribution of synphilin-1 in the pathogenesis of PD has been defined with the identification of an R621C mutation as a susceptibility factor for PD in two German patients. Extensive in vitro studies have determined the physiological functions of synphilin-1, identified novel synphilin-1-interacting proteins, and linked synphilin-1 to ubiquitin-mediated protein degradation. The present article provides an overview of the current concepts of the role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in PD. | |
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) | |
http://hdl.handle.net/10993/17139 | |
10.1007/s00441-004-0953-z |
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