Reference : Antiapoptotic effects of budipine.
Scientific journals : Article
Life sciences : Genetics & genetic processes
Antiapoptotic effects of budipine.
Muller, T. [> >]
Przuntek, H. [> >]
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit]
Mackowiak, A. [> >]
Journal of Neural Transmission
Yes (verified by ORBilu)
[en] Anti-Inflammatory Agents, Non-Steroidal ; Antiparkinson Agents/pharmacology ; Apoptosis/drug effects ; Cell Line ; Cell Line, Tumor ; Humans ; Interleukin-6/biosynthesis ; Piperidines/pharmacology ; Sympathetic Nervous System/pathology ; Tumor Necrosis Factor-alpha/biosynthesis
[en] Apoptosis is one essential step for neuronal death in the nigrostriatal region in patients with Parkinson's disease. Cytotoxic tumor necrosis factor-alpha (TNF-alpha) and the proinflammatory cytokine interleukin-6 (Il-6) provide a proapoptotic environment. We investigated the influence of the antiparkinsonian compound budipine on the release of TNF-alpha and Il-6 in peripheral blood mononuclear cells (PBMC) and on the degree of cisplatin induced apoptotic cell death in SH-SY 5Y human neuroblastoma cells. 10(-7), 10(-8), 10(-9) mol/l of budipine significantly reduced release of TNF-alpha and Il-6 in PBMC and decreased apoptotic cell death after 50 hours and 74 hours in the SH-SY 5Y cells. Our results suggest, that budipine administration provides an antiapoptotic environment and slows neuronal apoptotic and inflammatory mediated loss of neurons.
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)

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