| Reference : Antiapoptotic effects of budipine. |
| Scientific journals : Article | |||
| Life sciences : Genetics & genetic processes | |||
| http://hdl.handle.net/10993/17136 | |||
| Antiapoptotic effects of budipine. | |
| English | |
| Muller, T. [> >] | |
| Przuntek, H. [> >] | |
Krüger, Rejko  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit] | |
| Mackowiak, A. [> >] | |
| 2004 | |
| Journal of Neural Transmission | |
| 111 | |
| 10-11 | |
| 1365-73 | |
| Yes (verified by ORBilu) | |
| 0300-9564 | |
| Austria | |
| [en] Anti-Inflammatory Agents, Non-Steroidal ; Antiparkinson Agents/pharmacology ; Apoptosis/drug effects ; Cell Line ; Cell Line, Tumor ; Humans ; Interleukin-6/biosynthesis ; Piperidines/pharmacology ; Sympathetic Nervous System/pathology ; Tumor Necrosis Factor-alpha/biosynthesis | |
| [en] Apoptosis is one essential step for neuronal death in the nigrostriatal region in patients with Parkinson's disease. Cytotoxic tumor necrosis factor-alpha (TNF-alpha) and the proinflammatory cytokine interleukin-6 (Il-6) provide a proapoptotic environment. We investigated the influence of the antiparkinsonian compound budipine on the release of TNF-alpha and Il-6 in peripheral blood mononuclear cells (PBMC) and on the degree of cisplatin induced apoptotic cell death in SH-SY 5Y human neuroblastoma cells. 10(-7), 10(-8), 10(-9) mol/l of budipine significantly reduced release of TNF-alpha and Il-6 in PBMC and decreased apoptotic cell death after 50 hours and 74 hours in the SH-SY 5Y cells. Our results suggest, that budipine administration provides an antiapoptotic environment and slows neuronal apoptotic and inflammatory mediated loss of neurons. | |
| Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) | |
| http://hdl.handle.net/10993/17136 | |
| 10.1007/s00702-004-0157-4 |
There is no file associated with this reference.
All documents in ORBilu are protected by a user license.
