Reference : Antiapoptotic effects of budipine. |
Scientific journals : Article | |||
Life sciences : Genetics & genetic processes | |||
http://hdl.handle.net/10993/17136 | |||
Antiapoptotic effects of budipine. | |
English | |
Muller, T. [> >] | |
Przuntek, H. [> >] | |
Krüger, Rejko ![]() | |
Mackowiak, A. [> >] | |
2004 | |
Journal of Neural Transmission | |
111 | |
10-11 | |
1365-73 | |
Yes (verified by ORBilu) | |
0300-9564 | |
Austria | |
[en] Anti-Inflammatory Agents, Non-Steroidal ; Antiparkinson Agents/pharmacology ; Apoptosis/drug effects ; Cell Line ; Cell Line, Tumor ; Humans ; Interleukin-6/biosynthesis ; Piperidines/pharmacology ; Sympathetic Nervous System/pathology ; Tumor Necrosis Factor-alpha/biosynthesis | |
[en] Apoptosis is one essential step for neuronal death in the nigrostriatal region in patients with Parkinson's disease. Cytotoxic tumor necrosis factor-alpha (TNF-alpha) and the proinflammatory cytokine interleukin-6 (Il-6) provide a proapoptotic environment. We investigated the influence of the antiparkinsonian compound budipine on the release of TNF-alpha and Il-6 in peripheral blood mononuclear cells (PBMC) and on the degree of cisplatin induced apoptotic cell death in SH-SY 5Y human neuroblastoma cells. 10(-7), 10(-8), 10(-9) mol/l of budipine significantly reduced release of TNF-alpha and Il-6 in PBMC and decreased apoptotic cell death after 50 hours and 74 hours in the SH-SY 5Y cells. Our results suggest, that budipine administration provides an antiapoptotic environment and slows neuronal apoptotic and inflammatory mediated loss of neurons. | |
Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group) | |
http://hdl.handle.net/10993/17136 | |
10.1007/s00702-004-0157-4 |
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