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Antiapoptotic effects of budipine.
Muller, T.; Przuntek, H.; Krüger, Rejko et al.
2004In Journal of Neural Transmission, 111 (10-11), p. 1365-73
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Keywords :
Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents/pharmacology; Apoptosis/drug effects; Cell Line; Cell Line, Tumor; Humans; Interleukin-6/biosynthesis; Piperidines/pharmacology; Sympathetic Nervous System/pathology; Tumor Necrosis Factor-alpha/biosynthesis
Abstract :
[en] Apoptosis is one essential step for neuronal death in the nigrostriatal region in patients with Parkinson's disease. Cytotoxic tumor necrosis factor-alpha (TNF-alpha) and the proinflammatory cytokine interleukin-6 (Il-6) provide a proapoptotic environment. We investigated the influence of the antiparkinsonian compound budipine on the release of TNF-alpha and Il-6 in peripheral blood mononuclear cells (PBMC) and on the degree of cisplatin induced apoptotic cell death in SH-SY 5Y human neuroblastoma cells. 10(-7), 10(-8), 10(-9) mol/l of budipine significantly reduced release of TNF-alpha and Il-6 in PBMC and decreased apoptotic cell death after 50 hours and 74 hours in the SH-SY 5Y cells. Our results suggest, that budipine administration provides an antiapoptotic environment and slows neuronal apoptotic and inflammatory mediated loss of neurons.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Disciplines :
Genetics & genetic processes
Author, co-author :
Muller, T.
Przuntek, H.
Krüger, Rejko ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Mackowiak, A.
Language :
English
Title :
Antiapoptotic effects of budipine.
Publication date :
2004
Journal title :
Journal of Neural Transmission
ISSN :
0300-9564
Volume :
111
Issue :
10-11
Pages :
1365-73
Peer reviewed :
Peer reviewed
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