No full text
Article (Scientific journals)
Selegiline stimulates biosynthesis of cytokines interleukin-1 beta and interleukin-6.
Wilfried, K.; Muller, T.; KRÜGER, Rejko et al.
1996In Neuroreport, 7 (18), p. 2847-8
Peer reviewed
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Humans; Interleukin-1/biosynthesis; Interleukin-6/biosynthesis; Monocytes/drug effects/metabolism; Neuroprotective Agents/pharmacology; Selegiline/pharmacology; Stimulation, Chemical
Abstract :
[en] Several lines of evidence indicate an immune-mediated pathophysiology of Parkinson's disease (PD) and Alzheimer's disease (AD). In clinical studies the monoamine oxidase-B inhibitor Selegiline appears to slow the progression of neurological deficits in PD and the cognitive decline in AD. The immune response to bacterial or viral infection and in chronic inflammatory processes is stimulated by an increased synthesis of the cytokines interleukin-1 beta (IL-1 beta) and subsequently interleukin-6 (IL-6). We investigated the influence of Selegiline on the synthesis of IL-1 beta and IL-6 in peripheral blood mononuclear cells (PBMC) from healthy blood donors cultured with or without Selegiline (10(-8)M, 10(-9)M or 10(-10)M) in a humidified atmosphere (7% CO2). Treatment of cultured PBMC with Selegiline significantly increased synthesis of both cytokines. The effect of Selegiline on cytokine biosynthesis may contribute to its putative neuroprotective properties.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
Disciplines :
Genetics & genetic processes
Author, co-author :
Wilfried, K.
Muller, T.
KRÜGER, Rejko ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Horst, P.
Language :
English
Title :
Selegiline stimulates biosynthesis of cytokines interleukin-1 beta and interleukin-6.
Publication date :
1996
Journal title :
Neuroreport
ISSN :
0959-4965
Volume :
7
Issue :
18
Pages :
2847-8
Peer reviewed :
Peer reviewed
Available on ORBilu :
since 27 June 2014

Statistics


Number of views
87 (2 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
11
Scopus citations®
without self-citations
10
OpenCitations
 
4
WoS citations
 
7

Bibliography


Similar publications



Contact ORBilu