Article (Scientific journals)
Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling
VOLLMER, Stefan; Kappler, Valérie; KACZOR, Jakub et al.
2009In Hepatology, 2009 (3)
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Abstract :
[en] The interleukin-6-type cytokine oncostatin M (OSM) acts via the Janus kinase/signal transducer and activator of transcription pathway as well as via activation of mitogen-activated protein kinases and is known to critically regulate processes such as liver development and regeneration, hematopoiesis, and angiogenesis, which are also determined by hypoxia with the hypoxia-inducible factor 1alpha (HIF1alpha) as a key component. Here we show that treatment of hepatocytes and hepatoma cells with OSM leads to an increased protein level of HIF1alpha under normoxic and hypoxic conditions. Furthermore, the OSM-dependent HIF1alpha increase is mediated via Janus kinase/signal transducer and activator of transcription 3 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 pathways. OSM-mediated HIF1alpha up-regulation did not result from an increase in HIF1alpha protein stability but from increased transcription from the HIF1alpha gene. In addition, we show that the OSM-induced HIF1alpha gene transcription and the resulting enhanced HIF1alpha protein levels are important for the OSM-dependent vascular endothelial growth factor and plasminogen activator inhibitor 1 gene induction associated with several diseases. Conclusion: HIF1alpha levels increase significantly after treatment of hepatocytes and hepatoma cells with OSM, and HIF1alpha contributes to OSM downstream signaling events, pointing to a cross-talk between cytokine and hypoxia signaling in processes such as liver development and regeneration. (HEPATOLOGY 2009.).
Disciplines :
Biochemistry, biophysics & molecular biology
Identifiers :
UNILU:UL-ARTICLE-2009-535
Author, co-author :
VOLLMER, Stefan ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Kappler, Valérie;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
KACZOR, Jakub;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Flügel, Daniela;  Chemistry Department, University of Kaiserslautern, Kaiserslautern, Germany
ROLVERING, Catherine ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Kato, Nobuyuki;  Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
Kietzmann, Thomas;  Chemistry Department, University of Kaiserslautern, Kaiserslautern, Germany
BEHRMANN, Iris ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
HAAN, Claude ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
External co-authors :
yes
Language :
English
Title :
Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling
Publication date :
2009
Journal title :
Hepatology
ISSN :
0270-9139
eISSN :
1527-3350
Publisher :
Wiley, Hoboken, United States - New Jersey
Volume :
2009
Issue :
3
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 22 April 2014

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