| Reference : Pax1, a member of the paired box-containing class of developmental control genes, is ... |
| Scientific journals : Article | |||
| Life sciences : Genetics & genetic processes | |||
| http://hdl.handle.net/10993/1271 | |||
| Pax1, a member of the paired box-containing class of developmental control genes, is mapped to human chromosome 20p11.2 by in situ hybridization (ISH and FISH). | |
| English | |
| Schnittger, S. [> >] | |
| Rao, V. V. [> >] | |
| Deutsch, U. [> >] | |
| Gruss, P. [> >] | |
Balling, Rudi  [] | |
| Hansmann, I. [> >] | |
| 1992 | |
| Genomics | |
| 14 | |
| 3 | |
| 740-4 | |
| Yes (verified by ORBilu) | |
| 0888-7543 | |
| 1089-8646 | |
| UNITED STATES | |
| [en] Animals ; Chromosome Mapping ; Chromosomes, Human, Pair 20 ; Cricetinae ; DNA-Binding Proteins/genetics ; Genes, Homeobox ; Humans ; Hybrid Cells ; In Situ Hybridization ; In Situ Hybridization, Fluorescence ; Paired Box Transcription Factors ; Transcription Factors/genetics | |
| [en] Pax-1, a member of a murine multigene family, belongs to the paired box-containing class of developmental control genes first identified in Drosophila. The Pax-1 gene encodes a sequence-specific DNA-binding protein with transcriptional activating properties and has been found to be mutated in the autosomal recessive mutation undulated (un) on mouse chromosome 2 with vertebral anomalies along the entire rostrocaudal axis. By radioactive in situ hybridization (ISH) using a fragment from the murine Pax-1 paired box that is almost identical to the respective sequences from the cognate human gene HuP48 and fluorescence in situ hybridization (FISH) using a complete mouse Pax-1 cDNA, we have assigned the human homologue of murine Pax-1, the PAX1 locus, to chromosome 20p. The map position of PAX1 after FISH (FL-pter value of 0.34 +/- 0.04) corresponds to band p11.2. These results confirm the exceptional homology between human chromosome 20 and the distal segment of mouse chromosome 2, extending from bands F to G, and add PAX1 to the group of genes on 20p like PTPA, PRNP, SCG1, BMP2A, which are located in proximity on both chromosomes. | |
| http://hdl.handle.net/10993/1271 |
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