| Reference : Pax: a murine multigene family of paired box-containing genes. |
| Scientific journals : Article | |||
| Life sciences : Genetics & genetic processes | |||
| http://hdl.handle.net/10993/1266 | |||
| Pax: a murine multigene family of paired box-containing genes. | |
| English | |
| Walther, C. [> >] | |
| Guenet, J. L. [> >] | |
| Simon, D. [> >] | |
| Deutsch, U. [> >] | |
| Jostes, B. [> >] | |
| Goulding, M. D. [> >] | |
| Plachov, D. [> >] | |
Balling, Rudi  [] | |
| Gruss, P. [> >] | |
| 1991 | |
| Genomics | |
| 11 | |
| 2 | |
| 424-34 | |
| Yes (verified by ORBilu) | |
| 0888-7543 | |
| 1089-8646 | |
| UNITED STATES | |
| [en] Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Mapping ; Cloning, Molecular ; Crosses, Genetic ; DNA Probes ; Drosophila/genetics ; Genes, Regulator/genetics ; Haplotypes ; Mice/genetics ; Molecular Sequence Data ; Multigene Family/genetics ; Polymorphism, Restriction Fragment Length ; Reading Frames ; Sequence Alignment | |
| [en] A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of Drosophila. To date five murine paired box-containing genes (Pax genes) have been described and one, Pax-1, has been associated with the developmental mutant phenotype undulated. Here we describe the paired boxes of three novel Pax genes, Pax-4, Pax-5, and Pax-6. Comparison of the eight murine paired domains of the mouse, the five Drosophila paired domains, and the three human paired domains shows that they fall into six distinct classes: class I comprises Pox meso, Pax-1, and HuP48; class II paired, gooseberry-proximal, gooseberry-distal, Pax-3, Pax-7, HuP1, and HuP2; class III Pax-2, Pax-5, and Pax-8; class IV Pax-4; class V Pox neuro; and class VI Pax-6. Pax-1 and the human gene HuP48 have identical paired domains, as do Pax-3 and HuP2 as well as Pax-7 and HuP1, and are likely to represent homologous genes in mouse and man. Identical intron-exon structure and extensive sequence homology of their paired boxes suggest that several Pax genes represent paralogs. The chromosomal location of all novel Pax genes and of Pax-3 and Pax-7 has been determined and reveals that they are not clustered. | |
| http://hdl.handle.net/10993/1266 |
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