Reference : Pax: a murine multigene family of paired box-containing genes.
Scientific journals : Article
Life sciences : Genetics & genetic processes
Pax: a murine multigene family of paired box-containing genes.
Walther, C. [> >]
Guenet, J. L. [> >]
Simon, D. [> >]
Deutsch, U. [> >]
Jostes, B. [> >]
Goulding, M. D. [> >]
Plachov, D. [> >]
Balling, Rudi mailto []
Gruss, P. [> >]
Yes (verified by ORBilu)
[en] Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Mapping ; Cloning, Molecular ; Crosses, Genetic ; DNA Probes ; Drosophila/genetics ; Genes, Regulator/genetics ; Haplotypes ; Mice/genetics ; Molecular Sequence Data ; Multigene Family/genetics ; Polymorphism, Restriction Fragment Length ; Reading Frames ; Sequence Alignment
[en] A murine multigene family has been identified that shares a conserved sequence motif, the paired box, with developmental control and tissue-specific genes of Drosophila. To date five murine paired box-containing genes (Pax genes) have been described and one, Pax-1, has been associated with the developmental mutant phenotype undulated. Here we describe the paired boxes of three novel Pax genes, Pax-4, Pax-5, and Pax-6. Comparison of the eight murine paired domains of the mouse, the five Drosophila paired domains, and the three human paired domains shows that they fall into six distinct classes: class I comprises Pox meso, Pax-1, and HuP48; class II paired, gooseberry-proximal, gooseberry-distal, Pax-3, Pax-7, HuP1, and HuP2; class III Pax-2, Pax-5, and Pax-8; class IV Pax-4; class V Pox neuro; and class VI Pax-6. Pax-1 and the human gene HuP48 have identical paired domains, as do Pax-3 and HuP2 as well as Pax-7 and HuP1, and are likely to represent homologous genes in mouse and man. Identical intron-exon structure and extensive sequence homology of their paired boxes suggest that several Pax genes represent paralogs. The chromosomal location of all novel Pax genes and of Pax-3 and Pax-7 has been determined and reveals that they are not clustered.

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