Reference : undulated, a mutation affecting the development of the mouse skeleton, has a point mu... |
Scientific journals : Article | |||
Life sciences : Genetics & genetic processes | |||
http://hdl.handle.net/10993/1255 | |||
undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1. | |
English | |
Balling, Rudi ![]() | |
Deutsch, U. [> >] | |
Gruss, P. [> >] | |
1988 | |
Cell | |
55 | |
3 | |
531-5 | |
Yes (verified by ORBilu) | |
0092-8674 | |
1097-4172 | |
UNITED STATES | |
[en] Animals ; Base Sequence ; Blotting, Southern ; DNA/genetics ; Gene Expression Regulation ; Homozygote ; Mice ; Mice, Mutant Strains ; Molecular Sequence Data ; Mutation ; Spine/embryology | |
[en] undulated (un) homozygous mice exhibit vertebral malformations along the entire rostro-caudal axis. Pax 1, a murine paired box-containing gene, is expressed in ventral sclerotome cells and later in intervertebral disks along the entire vertebral column. We localized the Pax 1 gene on chromosome 2 between beta 2-microglobulin and the agouti locus to an area where un maps. DNA analysis of the un mutant revealed a point mutation in a highly conserved part of the paired box of Pax 1, leading to a Gly-Ser replacement. The chromosomal location and the mutation in the paired box of un mice in conjunction with Pax 1 gene expression in wild-type mice implicate a causative role of Pax 1 in generation of the vertebral column. | |
http://hdl.handle.net/10993/1255 |
There is no file associated with this reference.
All documents in ORBilu are protected by a user license.