Reference : Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach |
Scientific journals : Article | |||
Life sciences : Biotechnology Life sciences : Multidisciplinary, general & others Human health sciences : Neurology Human health sciences : Multidisciplinary, general & others | |||
Systems Biomedicine | |||
http://hdl.handle.net/10993/46078 | |||
Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach | |
English | |
Giovagnoni, Caterina [> >] | |
Ali, Muhammad [> >] | |
Eijssen, Lars M. T. [> >] | |
Maes, Richard [> >] | |
Choe, Kyonghwan [> >] | |
Mulder, Monique [> >] | |
Kleinjans, Jos [> >] | |
del Sol, Antonio [] | |
Glaab, Enrico ![]() | |
Mastroeni, Diego [> >] | |
Delvaux, Elaine [> >] | |
Coleman, Paul [> >] | |
Losen, Mario [> >] | |
Pishva, Ehsan [> >] | |
Martinez, Pilar Martinez [> >] | |
van den Hove, Daniel L. A. [> >] | |
2021 | |
Neurobiology of Aging | |
Elsevier | |
in press | |
in press | |
Yes (verified by ORBilu) | |
International | |
0197-4580 | |
1558-1497 | |
New York | |
Netherlands | |
[en] Alzheimer's disease ; aging ; sphingolipids ; regulatory networks ; pathways ; bioinformatics ; epigenetics ; disease network analysis | |
[en] Sphingolipids (SLs) are bioactive lipids involved in various important physiological functions.
The SL pathway has been shown to be affected in several brain-related disorders, including Alzheimer’s disease (AD). Recent evidence suggests that epigenetic dysregulation plays an important role in the pathogenesis of AD as well. Here, we use an integrative approach to better understand the relationship between epigenetic and transcriptomic processes in regulating SL function in the middle temporal gyrus of AD patients. Transcriptomic analysis of 252 SL-related genes, selected based on GO term annotations, from 46 AD patients and 32 healthy age-matched controls, revealed 103 differentially expressed SL-related genes in AD patients. Additionally, methylomic analysis of the same subjects revealed parallel hydroxymethylation changes in PTGIS, GBA, and ITGB2 in AD. Subsequent gene regulatory network-based analysis identified three candidate genes, i.e. SELPLG, SPHK1 and CAV1 whose alteration holds the potential to revert the gene expression program from a diseased towards a healthy state. Together, this epigenomic and transcriptomic approach highlights the importance of SL-related genes in AD, and may provide novel biomarkers and therapeutic alternatives to traditionally investigated biological pathways in AD. | |
Luxembourg Centre for Systems Biomedicine (LCSB): Computational Biology (Del Sol Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) | |
Fonds National de la Recherche - FnR ; Fondation Wivine Luxembourg | |
EPIGE(NE5HT)ICS-AD | |
Researchers ; Professionals ; Students | |
http://hdl.handle.net/10993/46078 | |
The link to the original publication will be provided once available. | |
FnR ; FNR10243098 > Antonio Del Sol Mesa > EPIGE(NE5HT)ICS-AD > Targeting Epigenetic Dysregulation In The Brainstem In Alzheimer’S Disease > 01/08/2016 > 31/07/2019 > 2015 |
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