Reference : Nectarine promotes longevity in Drosophila melanogaster.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/41444
Nectarine promotes longevity in Drosophila melanogaster.
English
Boyd, Olga mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Weng, Peter [> >]
Sun, Xiaoping [> >]
Alberico, Thomas [> >]
Laslo, Mara [> >]
Obenland, David M. [> >]
Kern, Bradley [> >]
Zou, Sige [> >]
2011
Free radical biology & medicine
50
11
1669-78
Yes (verified by ORBilu)
International
0891-5849
1873-4596
United States
[en] Animals ; Animals, Genetically Modified ; Antioxidants/administration & dosage ; Diet ; Drosophila melanogaster/physiology ; Female ; Fertility/drug effects/genetics ; Fruit ; Gene Expression Regulation ; Longevity/drug effects ; Motor Activity/drug effects ; Mutation/genetics ; Oxidative Stress/drug effects/genetics ; Peroxiredoxins/genetics/metabolism ; Phosphoenolpyruvate Carboxykinase (ATP)/genetics/metabolism ; Plant Extracts/administration & dosage ; Superoxide Dismutase/genetics/metabolism ; Superoxide Dismutase-1
[en] Fruits containing high antioxidant capacities and other bioactivities are ideal for promoting longevity and health span. However, few fruits are known to improve the survival and health span in animals, let alone the underlying mechanisms. Here we investigate the effects of nectarine, a globally consumed fruit, on life span and health span in Drosophila melanogaster. Wild-type flies were fed standard, dietary restriction (DR), or high-fat diet supplemented with 0-4% nectarine extract. We measured life span, food intake, locomotor activity, fecundity, gene expression changes, and oxidative damage indicated by the level of 4-hydroxynonenal-protein adduct in these flies. We also measured life span, locomotor activity, and oxidative damage in sod1 mutant flies on the standard diet supplemented with 0-4% nectarine. Supplementation with 4% nectarine extended life span, increased fecundity, and decreased expression of some metabolic genes, including a key gluconeogenesis gene, PEPCK, and oxidative stress-response genes, including peroxiredoxins, in female wild-type flies fed the standard, DR, or high-fat diet. Nectarine reduced oxidative damage in wild-type females fed the high-fat diet. Moreover, nectarine improved the survival of and reduced oxidative damage in female sod1 mutant flies. Together, these findings suggest that nectarine promotes longevity and health span partly by modulating glucose metabolism and reducing oxidative damage.
http://hdl.handle.net/10993/41444
Published by Elsevier Inc.

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