Article (Scientific journals)
Mitochondrial morphology provides a mechanism for energy buffering at synapses.
Garcia, Guadalupe Clara; Bartol, Thomas M.; Phan, Sébastien et al.
2019In Scientific Reports, 9, p. 18306
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Abstract :
[en] Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to ensure cellular energy homeostasis. While these processes are well established, substantial evidence indicates that the internal structure is also highly variable in dependence on metabolic conditions. However, a quantitative mechanistic understanding of how mitochondrial morphology affects energetic states is still elusive. To address this question, we here present an agent-based multiscale model that integrates three-dimensional morphologies from electron microscopy tomography with the molecular dynamics of the main ATP producing components. We apply our modeling approach to mitochondria at the synapse which is the largest energy consumer within the brain. Interestingly, comparing the spatiotemporal simulations with a corresponding space-independent approach, we find minor spatial effects when the system relaxes toward equilibrium but a qualitative difference in fluctuating environments. These results suggest that internal mitochondrial morphology is not only optimized for ATP production but also provides a mechanism for energy buffering and may represent a mechanism for cellular robustness. IM
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Garcia, Guadalupe Clara ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Bartol, Thomas M.
Phan, Sébastien
Bushong, Eric A.
Perkins, Guy
Sejnowski, Terrence J.
Ellisman, Mark H.
Skupin, Alexander  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
yes
Language :
English
Title :
Mitochondrial morphology provides a mechanism for energy buffering at synapses.
Publication date :
2019
Journal title :
Scientific Reports
ISSN :
2045-2322
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
9
Pages :
18306
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 23 December 2019

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