Reference : Mitochondrial morphology provides a mechanism for energy buffering at synapses.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Mitochondrial morphology provides a mechanism for energy buffering at synapses.
Garcia, Guadalupe Clara mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Bartol, Thomas M. [> >]
Phan, Sébastien [> >]
Bushong, Eric A. [> >]
Perkins, Guy [> >]
Sejnowski, Terrence J. [> >]
Ellisman, Mark H. [> >]
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Scientific reports
Yes (verified by ORBilu)
[en] Mitochondria as the main energy suppliers of eukaryotic cells are highly dynamic organelles that fuse, divide and are transported along the cytoskeleton to ensure cellular energy homeostasis. While these processes are well established, substantial evidence indicates that the internal structure is also highly variable in dependence on metabolic conditions. However, a quantitative mechanistic understanding of how mitochondrial morphology affects energetic states is still elusive. To address this question, we here present an agent-based multiscale model that integrates three-dimensional morphologies from electron microscopy tomography with the molecular dynamics of the main ATP producing components. We apply our modeling approach to mitochondria at the synapse which is the largest energy consumer within the brain. Interestingly, comparing the spatiotemporal simulations with a corresponding space-independent approach, we find minor spatial effects when the system relaxes toward equilibrium but a qualitative difference in fluctuating environments. These results suggest that internal mitochondrial morphology is not only optimized for ATP production but also provides a mechanism for energy buffering and may represent a mechanism for cellular robustness. IM

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