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Late heartbeat-evoked potentials, indicators of cortical representation of interoceptive signal processing, are associated with survival after cardiac arrest
Schulz, André; Stammet, Pascal; Dierolf, Angelika et al.
2018In Hennig, J.; Stark, R. (Eds.) Abstractband Psychologie und Gehirn 2018
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Abstract :
[en] Rationale: Cardiac arrest (CA) is a serious condition characterized by high mortality rates, even after initial successful resuscitation, mainly due to neurological damage. Whether brain-heart communication is associated with outcome after CA is unknown. Heartbeat-evoked brain potentials (HEPs) represent neurophysiological indicators of brain-heart communication, as they reflect cortical representation of interoceptive signal processing. The aim of this study was to address the association between HEPs and survival after CA. Methods: HEPs were calculated from resting EEG/ECG in 55 CA patients 24 h after resuscitation. All patients were treated with targeted temperature management and a standardized sedation protocol during assessment. We investigated the association between HEP amplitude (180{320 ms, 455{595 ms, 860{1000 ms) and 6-month survival. Results: Twenty-five of 55 patients (45%) were still alive at 6-month follow-up. Survivors showed a higher HEP amplitude at frontopolar and frontal electrodes in the late HEP interval than non-survivors. This effect remained significant after controlling for between-group differences in terms of age, Fentanyl dose, and time lag between resuscitation and EEG assessment. There were no group differences in heart rate or heart rate variability. Conclusion: Brain-heart communication, as re ected by HEPs, is associated with survival after CA. Cardiovascular autonomic arousal may not be involved in mediating this effect. Adequate cortical representation of interoceptive signals may be essential to preserve cariovascular health and should be in the focus of prevention strategies. Future studies should address the brain-heart axis in CA.
Disciplines :
Neurosciences & behavior
Author, co-author :
Schulz, André  ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Stammet, Pascal
Dierolf, Angelika ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Vögele, Claus ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Beyenburg, Stefan
Werer, Christophe
Devaux, Yvan
External co-authors :
no
Language :
English
Title :
Late heartbeat-evoked potentials, indicators of cortical representation of interoceptive signal processing, are associated with survival after cardiac arrest
Publication date :
2018
Event name :
44. Tagung "Psychologie und Gehirn" 2018
Event organizer :
DGPA und DGPs Fachgruppe "Biologische Psychologie und Neuropsychologie"
Event place :
Gießen, Germany
Event date :
31-05-2018 to 02-06-2018
Audience :
International
Main work title :
Abstractband Psychologie und Gehirn 2018
Author, co-author :
Hennig, J.
Stark, R.
Pages :
112
Peer reviewed :
Peer reviewed
Available on ORBilu :
since 18 August 2018

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