Article (Scientific journals)
Late heartbeat-evoked potentials are associated with survival after cardiac arrest
Schulz, André; Stammet, P.; Dierolf, Angelika et al.
2018In Resuscitation, 126 (1), p. 7-13
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Abstract :
[en] RATIONALE: Cardiac arrest (CA) is a serious condition characterized by high mortality rates, even after initial successful resuscitation, mainly due to neurological damage. Whether brain-heart communication is associated with outcome after CA is unknown. Heartbeat-evoked brain potentials (HEPs) represent neurophysiological indicators of brain-heart communication. The aim of this study was to address the association between HEPs and survival after CA. METHODS: HEPs were calculated from resting EEG/ECG in 55 CA patients 24 hours after resuscitation. All patients were treated with targeted temperature management and a standardized sedation protocol during assessment. We investigated the association between HEP amplitude (180- 320 ms, 455-595 ms, 860-1000 ms) and 6-month survival. RESULTS: Twenty-five of 55 patients (45%) were still alive at 6-month follow-up. Survivors showed a higher HEP amplitude at frontopolar and frontal electrodes in the late HEP interval than non-survivors. This effect remained significant after controlling for between-group differences in terms of age, Fentanyl dose, and time lag between resuscitation and EEG assessment. There were no group differences in heart rate or heart rate variability. CONCLUSION: Brain-heart communication, as reflected by HEPs, is associated with survival after CA. Future studies should address the brain-heart axis in CA.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Schulz, André  ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Stammet, P.
Dierolf, Angelika ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Vögele, Claus ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Beyenburg, S.
Werer, C.
Devaux, Y.
External co-authors :
no
Language :
English
Title :
Late heartbeat-evoked potentials are associated with survival after cardiac arrest
Publication date :
May 2018
Journal title :
Resuscitation
ISSN :
0300-9572
Publisher :
Elsevier North Holland Biomedical Press, Limerick, Ireland
Volume :
126
Issue :
1
Pages :
7-13
Peer reviewed :
Peer reviewed
Available on ORBilu :
since 12 February 2018

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