Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

Kaas, A.; Pfleger, C.; Kharagjitsingh, A.V.; Schloot, N.C.; Hansen, L.; Buschard, K.; Koeleman, B.P.; Roep, B.O.; Mortensen, H.B.; Alizadeh, B.Z.; De Beaufort, Carine

Reference : Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/10993/27360

Title :	Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes
Language :	English
Author, co-author :	Kaas, A. [> >]
	Pfleger, C. [> >]
	Kharagjitsingh, A.V. [> >]
	Schloot, N.C. [> >]
	Hansen, L. [> >]
	Buschard, K. [> >]
	Koeleman, B.P. [> >]
	Roep, B.O. [> >]
	Mortensen, H.B. [> >]
	Alizadeh, B.Z. [> >]
	De Beaufort, Carine [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Publication date :	12-Dec-2011
Journal title :	Diabetic Medicine: A Journal of the British Diabetic Association
Publisher :	Blackwell Science
Peer reviewed :	Yes (verified by ORBi^lu)
ISSN :	0742-3071
e-ISSN :	1464-5491
City :	Oxford
Country :	United Kingdom
Keywords :	[en] childhood diabetes ; type 1 diabetes ; C-peptide ; disease progression ; children ; new diagnose
Abstract :	[en] AIMS: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. METHODS: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months. RESULTS: IL-10 decreased (P < 0.001) by 7.7% (1 month), 10.4% (6 months) and 8.6% (12 months) per year increase in age of child, while a twofold higher C-peptide concentration at 1 month (p = 0.06), 6 months (P = 0.0003) and 12 months (P = 0.02) was associated with 9.7%, 18.6% and 9.7% lower IL-10 levels, independent of each other. IL-10 concentrations did not associate with the disease progression groups. By contrast, IFNγ concentrations differed between the four progression groups at 6 and 12 months (P = 0.02 and P = 0.01, respectively); patients with rapid progressing disease had the highest levels at both time points. Distribution of IL-10 and IFNγ genotypes was equal among patients from the progression groups. CONCLUSION: IL-10 serum levels associate inversely with age and C-peptide. As age and C-peptide also associate, a triangular association is proposed. Genetic influence on IL-10 production seems to be masked by distinct disease mechanisms. Increased serum IFNγ concentrations associate with rapid disease progression. Functional genetic variants do not associate with a single progression pattern group, implying that disease processes override genetically predisposed cytokine production.
Permalink :	http://hdl.handle.net/10993/27360

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