Reference : Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in...
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes
Kaas, A. [> >]
Pfleger, C. [> >]
Kharagjitsingh, A.V. [> >]
Schloot, N.C. [> >]
Hansen, L. [> >]
Buschard, K. [> >]
Koeleman, B.P. [> >]
Roep, B.O. [> >]
Mortensen, H.B. [> >]
Alizadeh, B.Z. [> >]
De Beaufort, Carine mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Diabetic Medicine: A Journal of the British Diabetic Association
Blackwell Science
Yes (verified by ORBilu)
United Kingdom
[en] childhood diabetes ; type 1 diabetes ; C-peptide ; disease progression ; children ; new diagnose
[en] AIMS:
The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes.
Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months.
IL-10 decreased (P < 0.001) by 7.7% (1 month), 10.4% (6 months) and 8.6% (12 months) per year increase in age of child, while a twofold higher C-peptide concentration at 1 month (p = 0.06), 6 months (P = 0.0003) and 12 months (P = 0.02) was associated with 9.7%, 18.6% and 9.7% lower IL-10 levels, independent of each other. IL-10 concentrations did not associate with the disease progression groups. By contrast, IFNγ concentrations differed between the four progression groups at 6 and 12 months (P = 0.02 and P = 0.01, respectively); patients with rapid progressing disease had the highest levels at both time points. Distribution of IL-10 and IFNγ genotypes was equal among patients from the progression groups.
IL-10 serum levels associate inversely with age and C-peptide. As age and C-peptide also associate, a triangular association is proposed. Genetic influence on IL-10 production seems to be masked by distinct disease mechanisms. Increased serum IFNγ concentrations associate with rapid disease progression. Functional genetic variants do not associate with a single progression pattern group, implying that disease processes override genetically predisposed cytokine production.

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