Article (Scientific journals)
Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus.
Leidig-Bruckner, Gudrun; Grobholz, Sonja; Bruckner, Thomas et al.
2014In BMC Endocrine Disorders, 14, p. 33
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Keywords :
Absorptiometry, Photon; Adolescent; Adult; Aged; Aged, 80 and over; Bone Density; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 1/complications/physiopathology; Diabetes Mellitus, Type 2/complications/physiopathology; Female; Femur Neck/physiopathology; Follow-Up Studies; Fractures, Bone/epidemiology/etiology/pathology; Humans; Lumbar Vertebrae/physiopathology; Male; Middle Aged; Osteoporosis/epidemiology/etiology/pathology; Prevalence; Prognosis; Risk Factors; Young Adult
Abstract :
[en] BACKGROUND: Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type 1 and 2 diabetes. METHODS: Three hundred and ninety-eight consecutive diabetic patients from a single outpatient clinic received a standardized questionnaire on osteoporosis risk factors, and were evaluated for diabetes-related complications, HbA1c levels, and lumbar spine (LS) and femoral neck (FN) BMD. Of these, 139 (71 men, 68 women) type 1 and 243 (115 men, 128 women) type 2 diabetes patients were included in the study. BMD (T-scores and values adjusted for age, BMI and duration of disease) was compared between patient groups and between patients with type 2 diabetes and population-based controls (255 men, 249 women). RESULTS: For both genders, adjusted BMD was not different between the type 1 and type 2 diabetes groups but was higher in the type 2 group compared with controls (p < 0.0001). Osteoporosis prevalence (BMD T-score < -2.5 SD) at FN and LS was equivalent in the type 1 and type 2 diabetes groups, but lower in type 2 patients compared with controls (FN: 13.0% vs 21.2%, LS: 6.1% vs 14.9% men; FN: 21.9% vs 32.1%, LS: 9.4% vs 26.9% women). Osteoporosis prevalence was higher at FN-BMD than at LS-BMD. BMD was positively correlated with BMI and negatively correlated with age, but not correlated with diabetes-specific parameters (therapy, HbBA1c, micro- and macrovascular complications) in all subgroups. Fragility fracture prevalence was low (5.2%) and not different between diabetes groups. Fracture patients had lower BMDs compared with those without fractures; however, BMD T-score was above -2.5 SD in most patients. CONCLUSIONS: Diabetes-specific parameters did not predict BMD. Fracture occurrence was similar in both diabetes groups and related to lower BMD, but seems unrelated to the threshold T-score, <-2.5 SD. These results suggest that osteoporosis, and related fractures, is a clinically significant and commonly underestimated problem in diabetes patients.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Leidig-Bruckner, Gudrun
Grobholz, Sonja
Bruckner, Thomas
Scheidt-Nave, Christa
Nawroth, Peter
Schneider, Jochen ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
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Title :
Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus.
Publication date :
Journal title :
BMC Endocrine Disorders
Publisher :
BioMed Central, United Kingdom
Volume :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
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