| Innate and adaptive effects of inflammasomes on T cell responses |
| English |
| Dostert, Catherine  [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit] |
| Ludigs, Kristina [Department of Biochemistry, Chemin des Boveresses 155, 1066 Epalinges, Switzerland] |
| Guarda, Greta [Department of Biochemistry, Chemin des Boveresses 155, 1066 Epalinges, Switzerland] |
| 2013 |
| Current Opinion in Immunology |
| 25 |
| 3 |
| 359-365 |
| Yes (verified by ORBilu) |
| International |
| 0952-7915 |
| [en] CD8+ T lymphocyte ; CINCA syndrome ; T lymphocyte ; Th1 cell ; Th17 cell ; Adaptive Immunity ; Animals ; Caspase 1 ; Cytokines ; Humans ; Immunity, Innate ; Inflammasomes ; T-Lymphocytes |
| [en] Inflammasomes are protein complexes that form in response to pathogen-derived or host-derived stress signals. Their activation leads to the production of inflammatory cytokines and promotes a pyrogenic cell death process. The massive release of inflammatory mediators that follows inflammasome activation is a key event in alarming innate immune cells. Growing evidence also highlights the role of inflammasome-dependent cytokines in shaping the adaptive immune response, as exemplified by the capacity of IL-1β to support Th17 responses, or by the finding that IL-18 evokes antigen-independent IFN-γ secretion by memory CD8+ T cells. A deeper understanding of these mechanisms and on how to manipulate this powerful inflammatory system therefore represents an important step forward in the development of improved vaccine strategies. © 2013 Elsevier Ltd. |
| PP00P3_139094, SNSF, Swiss National Science Foundation |
| http://hdl.handle.net/10993/27259 |
| 10.1016/j.coi.2013.02.008 |
